ClinicaliQ Trial Snapshot
- A Study to Learn How Safe AZD6621 is, How Well it Works, and How it Moves Throughout the Body Over Time, in Adult Male Participants With Metastatic Prostate Cancer — Recruiting • Phase I • Oncology • NCT07192614.
- What is being tested: AZD6621, an experimental therapeutic agent, is undergoing evaluation for safety, tolerability, pharmacokinetics, and efficacy in adult male patients with metastatic prostate cancer, with administration via multiple delivery methods across different study modules.
- Patient eligibility overview: The trial recruits adult males diagnosed with metastatic prostate cancer; specific eligibility criteria (performance status, organ function, prior treatment history) are applied across study modules to ensure appropriate patient selection and safety monitoring.
Use This Page For
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying
This study is being conducted to learn more about the safety, tolerability, and effectiveness of an experimental treatment for metastatic prostate cancer called AZD6621. The study is split into different modules which will look at AZD6621 delivered by different methods. The study is also further split into 2 parts, Part A which will test different dose levels of AZD6621 to determine which doses are the best in terms of safety and side effects (dose escalation), and Part B will further test at least two AZD6621 doses in a larger group…
Eligibility Snapshot
- Capable of giving signed informed consent and complying to the study protocol. 2. Provision of signed and dated written Optional Genomics Initiative Research Information and Consent Form. 3. ≥ 18 years of age at the time of signing the informed consent form.
- Participants with: 1. Histologically confirmed diagnosis of metastatic adenocarcinoma of the prostate 2. Surgically or medically castrated, with serum testosterone levels ≤ 50 ng/dL (≤ 1.75 nmol/L) ≤ 28 days before first dose of study intervention. Participants without prior surgical castration must be currently taking and willing to continue LHRH agonist or antagonist therapy throughout the duration of the study intervention. 3. Castration-resistant prostate cancer as defined by disease progression despite castration by orchiectomy or ongoing ADT. 4. PSA at screening visit ≥ 1 ng/mL. 5. Provision of baseline fresh or archival tumor biopsy of prostate carcinoma is mandatory. 6. Evidence of disease progression within 6 months prior to screening with at least one of the following: 1. PSA progression defined by a minimum of 3 rising PSA levels with an interval of ≥ 1 week between each determination. 2. Radiographic progression of soft tissue disease by RECIST v1.1 criteria with or without PSA…
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.