ClinicaliQ Trial Snapshot
- Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease — Recruiting • Cardiology / Cardiovascular • NCT07768865.
- What is being tested: The study investigates arterial stiffness (hardening of arteries) in children and young people with hypertension and/or chronic kidney disease, examining whether these conditions accelerate vascular aging beyond normal developmental processes.
- Patient eligibility overview: The trial includes paediatric and young adult patients with chronic kidney disease and/or hypertension; specific age ranges and disease severity criteria would determine individual recruitment suitability.
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- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
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What This Trial Is Studying
Age related stiffening and hardening of the arteries is often a slow process, but some conditions such as chronic kidney disease (CKD), seem to increase the rate at which the arteries stiffen even during childhood. High blood pressure (BP) is well known to lead to arterial stiffening and is often seen in children and young people (CYP) with CKD. A greater risk of arterial stiffening has been reported in children CYP with CKD compared to healthy CYP and this is thought to be related to the development of high BP,…
Eligibility Snapshot
- : For CKD participants: * Aged 10-25 years at study entry. * Diagnosis of CKD confirmed on at least two GFR assessments 3-months apart; eGFR will be estimated using routine bedside formulae (modified Schwartz). Participants may include those on dialysis or those with a functioning kidney transplant. * Able to tolerate study investigations including 24-hour ABPM, echocardiogram, vascular assessments and MRI. For controls: * Aged 10-25 years at study entry * Having completed study measurements as part of other research being completed by the research group and having consented to their anonymised data being used in future research within the same research theme.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.