ClinicaliQ Trial Snapshot
- Comparing the Effects of Newer Pacemakers and Their Effects on the Heart and Valve Function in the Short-term. — Recruiting • Cardiology / Cardiovascular • NCT07534917.
- What is being tested: This trial compares conventional pacemakers (with transvalvular leads through the heart valve) against newer pacemaker designs to evaluate their effects on cardiac and valve function over the short-term period.
- Patient eligibility overview: The study includes patients requiring pacemaker implantation; those receiving conventional systems with leads passing through the right heart valve are compared against patients receiving newer pacemaker technologies designed to avoid or minimise valve involvement.
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- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
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What This Trial Is Studying
Conventional pacemakers involve placing a lead through a valve into the bottom right chamber of the heart. Research has shown that this approach is associated with an increased risk of valve dysfunction, mortality, and impairment of cardiac function. Newer pacemakers, such as leadless pacemakers and pacemakers that engage directly with the heart's native conduction system (known as left bundle branch pacemakers), are increasingly being adopted. However, the impact of these newer pacing technologies on cardiac function and the tricuspid valve, as well as how they compare with each other, remains…
Eligibility Snapshot
- : * All patients aged ≥18 referred for a permanent pacemaker at a single centre (Guys and St. Thomas' NHS Foundation Trust, UK) with high degree AV block, including Mobitz II and complete heart block, or scheduled AV node ablation, and LVEF ≥50%.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.