Oncology Cardiology / Cardiovascular Respiratory / COPD / Asthma Infectious Disease Gastroenterology Neurology Diabetes / Metabolic Women's Health Rheumatology Mental Health / Psychiatry Dermatology Rare Diseases Men's Health
Clinical Trial ● Currently Recruiting NCT05945043

Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion

Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion — Recruiting • Respiratory / COPD / Asthma • NCT05945043.

📅 04 Jun 2026 ⏱ 1 min read
Currently Recruiting
This trial is actively seeking participants in the UK. Discuss eligibility with your patient before referring.
Status
Currently Recruiting
NCT ID
NCT05945043
Sponsor
Guy's and St Thomas' NHS Foundation Trust
Start
2023-11-15
ClinicaliQ Trial Snapshot
  • Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion — Recruiting • Respiratory / COPD / Asthma • NCT05945043.
  • What is being tested: The study investigates how removing fluid from around the lungs (thoracocentesis) affects neural respiratory drive—the brain's signal to breathe—in patients with unilateral pleural effusions causing breathlessness.
  • Patient eligibility overview: The trial recruits patients with one-sided pleural effusions who experience breathlessness and require therapeutic fluid drainage as part of their clinical management.
Use This Page For
  • Quick orientation before opening the registry record.
  • Checking recruitment status, phase and sponsor at a glance.
  • Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying

The aim of this study is to better understand the relationship between pleural effusions and breathlessness in patients with unilateral pleural effusions and breathlessness who require pleural fluid removal for its management.

Eligibility Snapshot
  • : * Age 18 years or above * Has a unilateral pleural effusion AND 1. require thoracocentesis OR 2. chest drain insertion (main study only) OR 3. has an IPC in situ (main study only)

Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.

Full Trial Details
View this trial on the source registry
Eligibility criteria, protocol, and results when available
View Trial ↗
Share: Twitter/X LinkedIn
Related

Related Clinical Intelligence

Guidelines, Drug Science, safety briefs and education connected to this trial area.

Guideline
XVIVO Perfusion System (ex-situ machine perfusion) for assessing and reconditioning marginal lungs for transplantation: early-use assessment
Respiratory / COPD / Asthma · 21 Oct 2026
XVIVO Perfusion System enables ex-situ assessment of marginal donor lungs before transplantation, allowing objective evaluation of organ viability and function to improve…
View guideline →
Clinical Brief
AI sleep data could provide one-week early warning of flu and COVID-19
Respiratory / COPD / Asthma · UKHSA · 03 Sep 2026
Sleep-tracking apps analysing cough patterns can detect flu and COVID-19 approximately one week before symptom onset, potentially enabling early intervention and isolation…
View brief →
Guideline
Brensocatib for treating non-cystic fibrosis bronchiectasis in people 12 years and over (terminated evaluation)
Respiratory / COPD / Asthma · 25 Aug 2026
Evaluation terminated: Brensocatib for non-CF bronchiectasis is no longer under NICE appraisal—do not initiate new treatment pathways for this indication pending alternative…
View guideline →
Clinical Brief
Mum told to ‘prepare for worst’ urges others to get respiratory illness vaccine
Respiratory / COPD / Asthma · BBC Health · 13 Oct 2026
RSV vaccination in pregnancy is now available and recommended; Jo Goldsmith's case highlights the clinical value of preventing severe respiratory syncytial virus…
View brief →
Clinical Brief
What is postpartum psychosis and why is it central in the Lindsay Clancy trial?
Respiratory / COPD / Asthma · BBC Health · 19 Aug 2026
Postpartum psychosis is a rare but severe psychiatric emergency occurring in 1-2 per 1,000 deliveries, characterised by delusions, hallucinations, and disorganised thinking…
View brief →
Clinical Brief
Over one million children referred for mental healthcare – with anxiety the main reason
Respiratory / COPD / Asthma · BBC Health · 29 Jun 2026
Over one million children in England have been referred for mental healthcare, with anxiety as the leading presenting complaint, indicating a substantial…
View brief →