- Diagnostic and Therapeutic Applications in Microarrays in Organ Transplantation — Recruiting • NCT01299168.
- What is being tested: Microarray-based molecular diagnostic approaches to replace or supplement the current Banff Classification consensus system for identifying kidney transplant dysfunction, using data-driven methods alongside conventional biopsy analysis.
- Patient eligibility overview: Kidney transplant recipients undergoing protocol or clinically-indicated biopsies for suspected graft dysfunction, with samples analysed through both traditional Banff assessment and novel microarray molecular profiling technologies.
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
The current standard for biopsy-based diagnoses of dysfunction of kidney transplants is the Banff Classification which represents arbitrary international consensus. Recent data-driven approaches using molecular and conventional technologies indicate that mere consensus produces frequently incorrect diagnoses with potential harm to patients due to inappropriate treatment. To address this unmet need and improve diagnostics in the area of organ transplantation, the Alberta Transplant Applied Genomics Centre (ATAGC) has developed a new diagnostic system that combines the molecular and histopathological features of transplant biopsies, plus clinical and laboratory parameters, to create the…
- : * All kidney transplant recipients ≥18yrs of age undergoing a kidney biopsy for clinical indications, as determined by their physician or surgeon, will be eligible to enrol in the study.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.