ClinicaliQ Trial Snapshot
- Diurnal BP Patterns in Those at Increased Risk of CVD — Recruiting • Cardiology / Cardiovascular • NCT04522765.
- What is being tested: The clinical trial is evaluating chronotherapy (timing of anti-hypertensive medication administration) to restore normal diurnal blood pressure patterns, specifically the natural nocturnal dipping of >10% that occurs in healthy individuals.
- Patient eligibility overview: The study targets patients at increased cardiovascular disease risk who demonstrate abnormal blood pressure patterns, particularly those with absent or blunted nocturnal BP dipping (non-dippers).
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- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
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What This Trial Is Studying
In health, blood pressure (BP) falls at night by >10% compared with day-time values. This natural dipping pattern is important as without it there is an increased risk of cardiovascular disease (CVD). Recent evidence suggests that chronotherapy (taking anti-hypertensive medication at bedtime instead of in the morning) may enhance nocturnal BP dipping and reduce the risk of CVD events. There is therefore an urgent need to characterise diurnal BP patterns in patients who may be at risk of reduced nocturnal dipping in order to maximise protective therapy in all those…
Eligibility Snapshot
- : * Patients will be eligible to take part in the study if they attend NHS Lothian inpatient or outpatient services and can be classified as being at increased risk of CVD. This will include, but is not limited to, the following subgroups: 1. CKD as defined by the Kidney Disease Outcome Quality Initiative (K/DOQI) classification 2. AKI as defined by the Kidney Disease Improving Global Outcomes (KDIGO) classification 3. Small vessel vasculitis 4. Kidney transplant recipient 5. Kidney donor We will also recruit a healthy control group from the community.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.