ClinicaliQ Trial Snapshot
- EVERiST: Impact of Image Detected Accessory Pudendal Artery on Erection Recovery After Nerve Sparing Prostatectomy — Recruiting • Oncology • NCT07597798.
- What is being tested: The EVERiST trial investigates whether pre-operative imaging detection of accessory pudendal arteries influences erectile function recovery following nerve-sparing radical prostatectomy in prostate cancer patients.
- Patient eligibility overview: The trial includes men with localised prostate cancer planned for nerve-sparing radical prostatectomy, with stratification based on imaging-identified accessory pudendal artery anatomy to assess its prognostic significance for post-operative erectile dysfunction.
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What This Trial Is Studying
Prostate cancer is the most common cancer amongst men in the United Kingdom, and two common curative treatments are surgery to remove the prostate (radical prostatectomy) or radiotherapy. Both treatments can affect quality of life, mainly because of problems with erections and urinary leakage. Many men feel disappointed or regret their treatment choice because of changes in their sexual function. Surgeons often use a 'nerve-sparing' technique to reduce the risk of erectile dysfunction (ED), but many men still experience erection problems afterwards. A way to improve erectile function recovery after…
Eligibility Snapshot
- : * Men diagnosed with cT2-T3a N0 M0 PCa aged between 18 and 79 from all ethnic backgrounds. * Patients who underwent a prostate mpMRI before prostate biopsy. * Medically fit to undergo RARP. * Diagnostic quality prostate biopsies concordant with a diagnostic quality prostate mpMRI adequate to provide a surgical plan. * Scheduled for RARP with a recommendation of NVB spare based on multidisciplinary meetings informed by mpMRI, biopsy result and clinical factors. * Sexually active men with no to mild ED at baseline based on IIEF-EFD (>=24) questionnaire. * Preference to preserve erectile function for sexual intercourse. * Ability to read English sufficiently to understand PIS and able to give informed consent.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.