ClinicaliQ Trial Snapshot
- HTL0039732 in Participants With Advanced Solid Tumours — Recruiting • Phase I • Oncology • NCT05944237.
- What is being tested: HTL0039732, a novel therapeutic agent, is being evaluated as monotherapy and in combination regimens with atezolizumab and other established anti-cancer treatments in patients with advanced solid tumours.
- Patient eligibility overview: The trial includes patients with advanced solid tumours, with specific eligibility criteria determined by disease type and treatment combination arm; participants must have adequate organ function and performance status to tolerate the investigational therapy.
Use This Page For
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying
The purpose of this trial is to evaluate a new drug, HTL0039732, that will be administered on its own (as a monotherapy) and in combination with atezolizumab or with other approved anti-cancer therapies, in participants with advanced solid tumours.
Eligibility Snapshot
- : 1. Written (signed and dated) informed consent and capable of co-operating with investigational medicinal product administration and follow-up. 2. Phase 1, dose escalation phase Part A (HTL0039732 monotherapy): * Histologically or cytologically proven advanced solid tumour, refractory to conventional treatment, or for which no further conventional therapy is considered appropriate by the Investigator or is declined by the potential participant. * At least 1 measurable lesion according to RECIST v1.1, which (in the Investigator's opinion) has had objective radiological progression on or after the last therapy, or at least one assessable lesion e.g. pleural or peritoneal thickening that does not fulfil RECIST v1.1 criteria for measurable disease. * Consent to access and analysis of any available archival tissue or a fresh tumour sample at baseline, if archival tissue is unavailable. * Consent for fresh tumour biopsy sample(s) at time of PD, if the participant has accessible disease and is eligible to receive atezolizumab. Optional at time of disease progression. Phase 1 Part B: - Histologically proven advanced solid tumour where PGE2/EP4 signalling is believed to be more prevalent or significant (such as microsatellite stable colorectal cancer (MSS CRC), gastro-esophageal cancer, head and neck squamous cell carcinoma (HNSCC), mCRPC,…
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.