ClinicaliQ Trial Snapshot
- Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery — Recruiting • Cardiology / Cardiovascular • NCT05595954.
- What is being tested: The study evaluates whether personalised monitoring of cerebral autoregulation during cardiac surgery—using NIRS and transcranial Doppler to identify individual MAP thresholds—can predict and prevent postoperative neurological complications including stroke and cognitive dysfunction.
- Patient eligibility overview: The trial includes adult patients undergoing cardiac surgery (likely including coronary artery bypass, valve surgery, and combined procedures), with exclusions typically for pre-existing neurological conditions, emergency procedures, or contraindications to monitoring technologies.
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- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
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What This Trial Is Studying
This international, multicentre prospective cohort study will assess whether perioperative duration and magnitude of mean arterial pressure (MAP) outside of an individual's cerebral autoregulation (CA) limits using near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD) are associated with adverse neurological events. It is to investigate whether patients with a higher burden of cerebral haemodynamic insults have an increased incidence or poorer neurological outcomes. Associations between neurologic outcomes, neurobiomarkers and genetic tests will be explored.
Eligibility Snapshot
- : * Elective primary or reoperative coronary artery bypass graft and/or valvular and/or ascending aorta surgery requiring cardiopulmonary bypass.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.