- Intra-operative Detection of Positive Margins and Lymph Nodes in Breast Surgery — Recruiting • Oncology • NCT06977698.
- What is being tested: Novel dual optical imaging systems combining OCT-Raman spectroscopy (for lumpectomy specimens) and autofluorescence-Raman spectroscopy (for sentinel lymph nodes) to provide real-time, high-resolution intra-operative detection of positive surgical margins and lymph node involvement in breast cancer surgery.
- Patient eligibility overview: Women undergoing breast-conserving surgery (lumpectomy) with sentinel lymph node biopsy for breast cancer, assessed for intra-operative specimen analysis without requiring additional patient procedures or extended operative time.
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
In this project, the investigators will develop novel optical coherence tomography (OCT)-Raman spectroscopy and autofluorescence (AF)-Raman spectroscopy systems based on a selective sampling approach optimised for high-resolution analysis of whole lumpectomy specimens and sentinel lymph node (SLN) biopsies, respectively. The aim of using optical coherence tomography is not to detect cancer directly, but rather to identify adipose tissue so that large adipose regions can be excluded from subsequent Raman spectroscopy measurements. Although OCT has limited ability to distinguish tumour tissue from the surrounding normal stroma, adipose tissue exhibits a distinctive…
- * Patients undergoing breast surgery wide local excision (WLE). * Able to give informed consent. * Any age.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.