ClinicaliQ Trial Snapshot
- NAIF 2.0 – COGNIFY — Recruiting • Cardiology / Cardiovascular • NCT07824297.
- What is being tested: This observational study investigates whether intracranial dural arteriovenous fistulae (abnormal arterial-venous connections in the brain's protective membrane) impair the glymphatic system—the brain's waste-clearance mechanism—and whether treating these fistulae can restore normal glymphatic function.
- Patient eligibility overview: The study enrolls patients diagnosed with intracranial dural arteriovenous fistulae who are candidates for treatment, with detailed inclusion/exclusion criteria applied to ensure appropriate patient selection (specific criteria would be detailed in the full protocol).
Use This Page For
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying
The goal of this observational study is to learn whether intracranial dural arteriovenous fistulae, abnormal connections between arteries and veins in the covering of the brain, may affect a brain's waste-clearance system, known as the glymphatic system. The main question it aims to answer is: "Does glymphatic system function change after routine endovascular embolization of an intracranial dural arteriovenous fistula?" Participants who are already scheduled to receive endovascular embolization as part of their regular medical care will undergo advanced brain MRI before treatment and again about 6 months after treatment.…
Eligibility Snapshot
- : * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 to 99 years. * Angiographically confirmed diagnosis of unruptured intracranial dAVF. * Candidate for endovascular embolization treatment with curative intent. * Able to undergo Brain MRI.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.