- “Physiological vs Right Ventricular Pacing Outcome Trial Evaluated for bradyCardia Treatment” (PROTECT-HF) — Recruiting • Non-phase study • Cardiology / Cardiovascular • NCT05815745.
- What is being tested: PROTECT-HF compares right ventricular (RV) pacing—the established standard treatment for bradycardia—against physiological pacing approaches to determine which strategy produces better clinical outcomes in patients requiring permanent pacemaker implantation.
- Patient eligibility overview: The trial recruits patients with bradycardia who require permanent pacemaker therapy, though specific inclusion/exclusion criteria would determine whether patients have atrioventricular block, sick sinus syndrome, or other conduction abnormalities requiring intervention.
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
The PROTECT-HF multi-centre randomised controlled trial will compare two different pacing approaches for treating patients with slow heart rates. In it the investigators will compare a long-standing standard approach for pacing; right ventricular pacing, with a new form of pacing, physiological pacing (His and Left bundle area pacing) in 2600 patients. Patients will be allocated at random to receive either right ventricular pacing or physiological pacing. Endpoint measurements will be undertaken at baseline, and at six-monthly intervals post-randomisation. Treatment allocation will be blinded to the endpoint assessor and the patient.…
- We will recruit patients who are referred for clinically indicated pacemaker implantation Inclusion Criteria:
- Adults aged over 18 with left ventricular ejection fraction >35% and one or more of the following guideline based ventricular pacing indications: 1. Permanent or intermittent 3rd degree AV block 2. Permanent or intermittent Mobitz type II AV block 3. First Degree AV block with a pacing indication 4. Slow chronic Atrial Fibrillation or Proposed AV node ablation 5. Bifascicular block with a pacing indication 6. Trifascicular block with a pacing indication 7. Wenckebach with a pacing indication
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.