- Randomised Treatment of Acute Pancreatitis With Infliximab: Double-blind, Placebo-controlled, Multi-centre Trial (RAPID-I) — Recruiting • Phase II • NCT03684278.
- Infliximab did not improve outcomes in acute pancreatitis compared to placebo in this randomised controlled trial.
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This study evaluates the effectiveness and safety of infliximab in the treatment of acute pancreatitis in adults. A third of participants will receive one single dose of infliximab via infusion, another third will receive a higher dose of infliximab via infusion and the final third of participants will receive a placebo infusion. Conditions: Acute Pancreatitis Interventions: Infusion of 5 mg/kg Infliximab, Infusion of 10 mg/kg Infliximab, 0.9% Sodium Chloride (Placebo) Lead Sponsor: University of Liverpool Planned Enrollment: 240 participants