ClinicaliQ Trial Snapshot
- RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure — Recruiting • Non-phase study • Cardiology / Cardiovascular • NCT05568069.
- What is being tested: BRITISH is evaluating whether implantable cardioverter-defibrillators (ICDs) improve outcomes in non-ischaemic cardiomyopathy patients with myocardial scar and severe systolic heart failure, comparing ICD therapy against standard medical management alone.
- Patient eligibility overview: The trial recruits UK patients with non-ischaemic cardiomyopathy (heart failure from non-coronary causes), evidence of myocardial scarring, and severe left ventricular systolic dysfunction, randomised into two treatment groups.
Use This Page For
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying
BRITISH is a UK multicentre trial of patients who have been diagnosed with heart failure due to Non-Ischemic Cardiomyopathy (NICM, or heart failure that is not caused by blocked heart arteries. Participants will be randomised into two groups. Half the participants will receive an Implantable Cardioverter-Defibrillator (ICD) and the other half will not. The aim of the study will be to compare all-cause mortality (death from any cause) between these two groups at 36 months, and longer-term to 10 years. The study has the potential to change international heart failure…
Eligibility Snapshot
- : 1. A diagnosis of NICM on contrast-enhanced cardiovascular magnetic resonance imaging 2. LV scar on routine CMR (patient without scar can enter the registry) 3. New York Heart Association (NYHA) Heart Failure (HF) functional class I-III and severely impaired left ventricular function (LVEF ≤ 35% on any imaging modality) after a minimum of 3 months of treatment with optimal medical therapy (OMT) as recommended by National Institute for Health and Care Excellence (NICE) 4. Able and willing to provide informed consent
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.