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Clinical Trial Active — Not Recruiting Phase III NCT04662255

Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)

Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL) — Active Not Recruiting • Phase III • Oncology • NCT04662255.

📅 23 Sep 2026 ⏱ 1 min read
Active — Not Recruiting
Check the registry for current status and eligibility criteria.
Status
Active — Not Recruiting
Phase
Phase III
NCT ID
NCT04662255
Start
2021-04-08
Completion
2027-11
ClinicaliQ Trial Snapshot
  • Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL) — Active Not Recruiting • Phase III • Oncology • NCT04662255.
  • Pirtobrutinib versus standard BTK inhibitors for mantle cell lymphoma treatment comparison.

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What This Trial Is Studying

This is a study for participants with a type of blood cancer called mantle cell lymphoma (MCL). The main purpose is to compare pirtobrutinib (LOXO-305) to other drugs that work in a similar way that have already been approved by the United States Food and Drug Administration (US FDA). Participation could last up to two years, and possibly longer, if the disease does not progress. Conditions: Lymphoma, Mantle-Cell Interventions: Pirtobrutinib, Ibrutinib, Acalabrutinib, Zanubrutinib Lead Sponsor: Loxo Oncology, Inc. Planned Enrollment: 500 participants

Full Trial Details
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Eligibility criteria, protocol, and results when available
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