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Clinical Trial Active — Not Recruiting Phase III NCT04877691

Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus

Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus — Active Not Recruiting • Phase III • Rheumatology • NCT04877691.

📅 27 Jul 2026 ⏱ 1 min read
Active — Not Recruiting
Check the registry for current status and eligibility criteria.
Status
Active — Not Recruiting
Phase
Phase III
NCT ID
NCT04877691
Start
2021-06-08
Completion
2025-08-22
ClinicaliQ Trial Snapshot
  • Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus — Active Not Recruiting • Phase III • Rheumatology • NCT04877691.
  • Subcutaneous anifrolumab (an interferon-blocking drug) improved outcomes in moderate-to-severe lupus patients already on standard treatment.

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What This Trial Is Studying

The purpose of this study is evaluating the efficacy and safety of SC antifrolumab in adult patients with moderate -to-severe SLE despite receiving standard therapy Conditions: Systemic Lupus Erythematosus Interventions: Medi-546, Placebo Lead Sponsor: AstraZeneca Planned Enrollment: 367 participants

Full Trial Details
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Eligibility criteria, protocol, and results when available
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Related Clinical Intelligence

Guidelines, Drug Science, safety briefs and education connected to this trial area.

Guideline
2023 EULAR Recommendations for Systemic Lupus Erythematosus
Rheumatology · 30 Mar 2026
This EULAR guideline addresses 2023 EULAR Recommendations for Systemic Lupus Erythematosus in Rheumatology. Use it to review current recommendation wording, eligibility criteria,…
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Guideline
Systemic Lupus Erythematosus (BSR Guidelines)
Rheumatology · 27 Mar 2026
Diagnose SLE using combination of clinical features plus positive ANA with anti-dsDNA or anti-Smith antibodies, and refer to rheumatology if SLE suspected…
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Clinical Brief
‘I’ve never been this good’ – revolutionary immune reset puts lupus in remission
Rheumatology · BBC Health · 11 Jun 2026
Emerging immune reset therapy demonstrates potential to achieve drug-free remission in lupus patients, representing a significant shift from traditional long-term immunosuppressive management…
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Clinical Brief
‘I’ve never been this good’ – revolutionary immune reset puts lupus in remission
Rheumatology · BBC Health · 11 Jun 2026
Experimental immune reset treatment has induced drug-free remission in lupus patients during clinical trials, representing a significant advancement in disease management Patients…
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Guideline
Rheumatoid Arthritis in Adults: Management (NICE NG100)
Rheumatology · 25 Mar 2026
Start methotrexate within 3 months of persistent synovitis diagnosis, combined with short-term bridging corticosteroids • Adopt treat-to-target strategy aiming for remission or…
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Drug Science
JAK-STAT Pathway
Dermatology · 04 Apr 2026
JAK-STAT Pathway is a clinically relevant Drug Science explainer. The Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway is a central…
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