ClinicaliQ Trial Snapshot
- The Effect of Time-Restricted Eating in Cardiometabolic Health — Recruiting • Non-phase study • Cardiology / Cardiovascular • NCT05866406.
- What is being tested: Time-restricted eating (TRE)—limiting daily food intake to a 6-12 hour window—is being investigated for its effects on cardiometabolic health markers, with the hypothesis that metabolic improvements occur through nutrient sensing activation rather than caloric restriction alone.
- Patient eligibility overview: The trial targets adults with cardiometabolic risk factors or established disease (such as obesity, type 2 diabetes, or cardiovascular conditions), assessing whether TRE protocols can be safely implemented and sustained in human populations.
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What This Trial Is Studying
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day. In rodents, TRE improves metabolic function without caloric restriction, potentially by activating nutrient sensing mechanisms and effects on circadian oscillations. However, an understanding of the effect of TRE on cardiometabolic health in people is not clear and few studies have evaluated this issue. Accordingly, the investigators propose to conduct a randomized controlled trial in people with obesity and prediabetes to determine the effect of 9 h…
Eligibility Snapshot
- : * must be able to grant voluntary informed consent and comply with the study instructions * aged 25-75 years * men and women * body mass index 27-45 kg/m2 * fasting plasma glucose 5.6-6.9 mmol/L, or 2h oral glucose tolerance test plasma glucose 7.8-11.1 mmol/L or haemoglobin A1C 39-46 mmol/mol or homeostasis model assessment-insulin resistance (HOMA-IR) score ≥2.73 * self-reported habitual eating period ≥ 13 h per day
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.