ClinicaliQ Trial Snapshot
- The Scottish Aortic Stenosis LongiTudinal Imaging and biomarkeR (SALTIRE) Programme — Recruiting • Cardiology / Cardiovascular • NCT06047561.
- What is being tested: SALTIRE is investigating the underlying mechanisms driving aortic stenosis progression and post-valve replacement outcomes through longitudinal imaging (echocardiography every 6 months) combined with biomarker analysis to identify disease accelerators and predictive factors.
- Patient eligibility overview: The study recruits patients across the aortic stenosis disease spectrum, including those with asymptomatic or symptomatic disease at various stages of severity, as well as patients who have undergone aortic valve replacement, enabling comparison across disease trajectory.
Use This Page For
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying
The goal of this observational study is to understand the processes of what causes and accelerates the disease progress in aortic stenosis and following aortic valve replacement. Participants will undergo transthoracic echocardiography every 6 months, with annual visits for state-of-the-art scanning techniques including positron-emission tomography combined with computed tomography or magnetic resonance imaging with radiotracers designed to look at disease processes including fibrosis, calcification, inflammation and thrombosis activity.
Eligibility Snapshot
- : * Male or female aged >50 years * Provision of informed consent prior to any study specific procedures * Patients with bioprosthetic aortic valve replacements, including both surgically and transcatheter implanted valves * Patients with severe aortic stenosis (peak velocity >4.0 m/s; previously recruited patients) * Patients with moderate aortic stenosis (peak velocity 3.0-4.0 m/s; new prospectively recruited patients) * Patients with mild aortic stenosis (peak velocity 2.5-2.9 m/s; new prospectively recruited patients) * Patients with aortic sclerosis (tri-leaflet thickened aortic valve with no obstruction of ventricular outflow) * Age and sex-matched healthy volunteers
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.