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JAK Inhibitors: Updated Safety Signals, Patient Selection and Post-ORAL Surveillance

JAK inhibitors have transformed inflammatory diseases from rheumatoid arthritis to eczema — but post-marketing safety data has reshaped how we use them. Dr Anzal Qurbain unpacks the updated MHRA and E

🎓 Dr Anzal Qurbain 📅 3 April 2026 ⏰ 00:16:21
Independent Editorial
Public / open access

ClinicaliQ-created or curated content with no sponsor influence.

This on-demand webinar is a recorded episode from the Drug Class Explainers series.
Listen to the full session below and earn 0.5 CPD hours upon completion.

JAK inhibitors have transformed inflammatory diseases from rheumatoid arthritis to eczema — but post-marketing safety data has reshaped how we use them. Dr Anzal Qurbain unpacks the updated MHRA and EMA guidance on cardiovascular and malignancy risk, and how to select the right patient for these oral targeted therapies.

Use the slide outline alongside the recording for a structured review of the session.

JAK inhibitors — session overview

  • Why JAK-STAT signalling matters across immune-mediated inflammatory disease
  • Key therapeutic areas: rheumatology, dermatology and gastroenterology
  • Safety updates and patient-selection themes

JAK-STAT pathway basics

  • Cytokine receptor signalling through JAK1, JAK2, JAK3 and TYK2
  • STAT activation and downstream transcriptional effects
  • Why pathway selectivity is clinically relevant but not absolute

Where JAK inhibitors fit

  • Oral targeted therapy in inflammatory disease
  • Potential role after conventional systemic treatment or biologic therapy
  • Importance of matching indication, disease activity and patient risk profile

Safety signals and risk stratification

  • Major adverse cardiovascular events and thromboembolic risk as key discussion points
  • Infection risk, herpes zoster and baseline screening considerations
  • Age, smoking, cardiovascular disease and malignancy history as review factors

Practical monitoring

  • Baseline blood tests and risk assessment before initiation
  • Ongoing laboratory monitoring and adverse-event review
  • Shared decision-making and documentation of risk-benefit discussion

Clinical takeaways

  • JAK inhibitors are powerful pathway-targeted therapies, not simple anti-inflammatory tablets
  • Use current guidance, local protocols and individual risk assessment
  • Keep educational discussion separate from product-specific promotional claims
🎓
Dr Anzal Qurbain
Specialist Speaker
00:16:21
0.5 — UK CPD accredited
📅3 April 2026
🎓Dr Anzal Qurbain
🌐Watch on demand, online
Rheumatology
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