Cardiology / Cardiovascular
Cardiovascular guidance, trial updates, drug mechanisms and CPD resources for clinicians following rapidly changing prevention, heart failure and cardiometabolic evidence.
Latest Guidelines
Finerenone for treating chronic heart failure with preserved or mildly reduced ejection fraction
Finerenone is recommended as an option for chronic heart failure with preserved or mildly reduced ejection fraction (HFpEF/HFmrEF) and can be initiated in primary or secondary…
Aficamten for treating symptomatic obstructive hypertrophic cardiomyopathy
Patient selection: Consider aficamten for symptomatic obstructive hypertrophic cardiomyopathy patients who remain symptomatic despite optimised standard therapy (beta-blockers, non-dihydropyridine calcium channel blockers, or disopyramide), or who…
Netarsudil for treating open-angle glaucoma or ocular hypertension (terminated evaluation)
Netarsudil evaluation by NICE was terminated, indicating it is not recommended for routine use in NHS treatment pathways for open-angle glaucoma or ocular hypertension—continue using established…
Sotatercept for treating pulmonary arterial hypertension
Sotatercept is recommended as a treatment option for pulmonary arterial hypertension (PAH) in patients who meet NICE criteria; verify patient eligibility and existing PAH therapy status…
Artificial intelligence (AI)-assisted echocardiography analysis and reporting to support the diagnosis and monitoring of heart failure: early-use assessment
AI-assisted echocardiography can support faster preliminary analysis and reporting of echo images in heart failure patients, potentially reducing reporting delays and improving clinical workflow efficiency in…
Semaglutide for reducing the risk of major adverse cardiovascular events in people with cardiovascular disease and overweight or obesity
Semaglutide is recommended for adults with established cardiovascular disease and overweight/obesity to reduce major adverse cardiovascular events – consider prescribing as part of a comprehensive cardiovascular…
Trial Radar
Mechanisms of Atrial Pathoelectrophysiology in HCM
What is being tested: This research investigates the underlying electrophysiological mechanisms responsible for the increased incidence and treatment…
TrialThe Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
What is being tested: This trial investigates the origin of thrombi causing ischaemic stroke and examines whether thrombosis…
NAEarly Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS
Early aortic valve surgery guided by heart scarring markers may improve outcomes in asymptomatic patients with severe stenosis.
PHASE3Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
This is a phase 3, randomized, multicenter, vehicle-controlled, double-masked study to evaluate the efficacy and safety of intranasal…
Clinical News
Campaigners hold vigil as stroke unit closes
Stroke unit closure will redirect acute stroke patients to neighbouring hospitals in Taunton or Dorchester, potentially impacting treatment…
26 Aug 2026Man completes half marathon after two heart attacks
Key Takeaways for Clinical Practice Cardiac rehabilitation and secondary prevention can enable significant functional recovery post-myocardial infarction, with…
29 Jul 2026‘It was heartbreaking to attend a fertility appointment in a maternity unit’
Key Takeaways for Clinical Practice Fertility services co-location with maternity units causes significant emotional harm – patients experiencing…
28 Jul 2026Meet the teenagers calling for action on violence against women and girls
Teenage activists are mobilising public engagement on violence against women and girls (VAWG), highlighting widespread concern among younger…
Relevant Mechanisms
Coagulation Factor Xa/IIa — DOACs
Coagulation Factor Xa/IIa — DOACs is a clinically relevant Drug Science explainer. The coagulation cascade proceeds via two convergent pathways…
MechanismGLP-1 Receptor Agonism
GLP-1 Receptor Agonism is a clinically relevant Drug Science explainer. Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from intestinal…
MechanismHMG-CoA Reductase — Statins
HMG-CoA Reductase — Statins is a clinically relevant Drug Science explainer. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyses the rate-limiting step…
MechanismPCSK9 Inhibition
PCSK9 Inhibition is a clinically relevant Drug Science explainer. PCSK9 (proprotein convertase subtilisin/kexin type 9) is a serine protease secreted…
MechanismRAAS Pathway
RAAS Pathway is a clinically relevant Drug Science explainer. The renin-angiotensin-aldosterone system (RAAS) is a hormonal cascade governing blood pressure,…
CPD, Podcasts & Webinars
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