Neurology
Neurology guidelines, trial updates, mechanisms and education across headache, neuroinflammation, movement disorders and specialist prescribing.
Latest Guidelines
Oxybutynin hydrochloride for managing neurogenic detrusor overactivity in people 6 years and over with spinal cord injury or spina bifida (terminated appraisal)
Oxybutynin is effective for neurogenic detrusor overactivity in patients aged 6+ years with spinal cord injury or spina bifida—consider as first-line antimuscarinic therapy for managing symptoms…
2022 EAN/EFNS Guidelines on Dementia Diagnosis and Management
This EAN guideline addresses 2022 EAN/EFNS Guidelines on Dementia Diagnosis and Management in Neurology. Use it to review current recommendation wording, eligibility criteria, and implementation considerations…
2023 EAN Guidelines on the Management of Multiple Sclerosis
This EAN guideline addresses 2023 EAN Guidelines on the Management of Multiple Sclerosis in Neurology. Use it to review current recommendation wording, eligibility criteria, and implementation…
2022 EAN Guidelines on Epilepsy Management in Adults
This EAN guideline addresses 2022 EAN Guidelines on Epilepsy Management in Adults in Neurology. Use it to review current recommendation wording, eligibility criteria, and implementation considerations…
Transient Loss of Consciousness (NICE CG109)
Obtain detailed witness account documenting prodrome, colour during episode, duration of unconsciousness, injury pattern, and postictal confusion to distinguish between syncope and seizure Perform 12-lead ECG…
Motor Neurone Disease: Assessment and Management (NICE NG42)
Refer suspected MND urgently to a specialist neurology centre for diagnosis confirmation by an MND-experienced neurologist using clinical examination, EMG/NCS, imaging, and genetic testing where appropriate…
Trial Radar
Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
New drug BIA 28-6156 tested against placebo to slow motor decline in GBA gene-linked Parkinson's disease over 78…
PHASE2A Study of JNJ-64042056 in Participants With Preclinical Alzheimer’s Disease
An experimental drug tested to see if it slows tau protein buildup in early Alzheimer's disease using brain…
PHASE2Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous Systemic Sclerosis
What is being tested: Rapcabtagene autoleucel, a CAR-T cell therapy administered as a single infusion after lymphodepletion, compared…
NAClosed-loop TMS for Tremor
Phase-locked brain stimulation may reduce tremor in essential tremor and Parkinson's disease patients when timed to suppress tremor…
Clinical News
Anaemia and the new dementia link
Key Takeaways for Clinical Practice Anaemia has been identified as a newly recognised risk factor for dementia, suggesting…
16 Apr 2026Breakthrough £90,000 Alzheimer’s drugs unlikely to benefit patients, report suggests
New anti-amyloid monoclonal antibodies for Alzheimer's disease show clinically minimal benefits despite high cost (£90,000), with disease progression…
01 Apr 2026My daughter has childhood dementia and may not live past 16
Key Clinical Takeaways Childhood dementia represents a group of rare progressive neurodegenerative disorders with devastating outcomes—Sophia's case illustrates…
30 Mar 2026New hope for children with severe epilepsy
Researchers says millions of people globally could be carriers of the faulty gene behind the disorder. This update…
Relevant Mechanisms
CGRP Pathway — Migraine
CGRP Pathway — Migraine is a clinically relevant Drug Science explainer. Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide…
MechanismDopamine D2 Receptor
Dopamine D2 Receptor is a clinically relevant Drug Science explainer. Dopamine (DA) is a monoamine neurotransmitter with distinct functional roles…
MechanismS1P Receptor Modulation — MS/IBD
S1P Receptor Modulation — MS/IBD is a clinically relevant Drug Science explainer. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite generated…
MechanismSerotonin/Noradrenaline Reuptake
Serotonin/Noradrenaline Reuptake is a clinically relevant Drug Science explainer. Serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (norepinephrine, NA) are monoamine neurotransmitters with…
CPD, Podcasts & Webinars
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