Respiratory / COPD / Asthma
Respiratory guidelines, trial intelligence, inhaled and biologic therapy mechanisms, and education across asthma, COPD and severe respiratory disease.
Latest Guidelines
XVIVO Perfusion System (ex-situ machine perfusion) for assessing and reconditioning marginal lungs for transplantation: early-use assessment
XVIVO Perfusion System enables ex-situ assessment of marginal donor lungs before transplantation, allowing objective evaluation of organ viability and function to improve transplant outcomes and reduce…
Brensocatib for treating non-cystic fibrosis bronchiectasis in people 12 years and over (terminated evaluation)
Evaluation terminated: Brensocatib for non-CF bronchiectasis is no longer under NICE appraisal—do not initiate new treatment pathways for this indication pending alternative guidance from your local…
Mepolizumab for maintenance treatment of uncontrolled chronic obstructive pulmonary disease with raised blood eosinophils
Mepolizumab is recommended for patients with uncontrolled COPD and blood eosinophils ≥100 cells/μL; check eosinophil levels before initiating treatment as this is a mandatory eligibility criterion.…
UK Achondroplasia Network’s consensus guideline for multidisciplinary care of children and young people with achondroplasia: NICE review
Establish multidisciplinary team review at diagnosis and at key developmental stages (infancy, pre-school, school age, adolescence) to monitor for complications including spinal stenosis, foramen magnum stenosis,…
Digital technologies to support self-management of asthma: early-use assessment
Use digital asthma self-management tools (apps, web platforms, wearables) as adjuncts to standard care to help patients monitor symptoms, track triggers, and improve medication adherence—particularly beneficial…
Digital technologies for applying algorithms to spirometry to support asthma and COPD diagnosis in primary care and community diagnostic centres: early-use assessment
Digital spirometry algorithms can improve diagnostic accuracy for asthma and COPD in primary care and community diagnostic centres, potentially reducing unnecessary referrals to secondary care and…
Trial Radar
A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer’s Disease
What is being tested: SAR448851, a novel once-daily oral medication, is being evaluated in a randomized, placebo-controlled Phase…
NAID93/GLA-SE Vaccination + BCG Challenge
Novel TB vaccine ID93/GLA-SE tested for safety and immune response in BCG-vaccinated and unvaccinated volunteers using aerosol challenge.
NAOPM- MEG in Non-immune And iMmune-medIated Neurological Disease
What is being tested: Optically Pumped Magnetometer (OPM)-MEG brain imaging technology to detect abnormal neural activity patterns in…
PHASE2A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
Treatment being tested: PF-07275315, a novel investigational medicine, is being evaluated for efficacy and safety in patients with…
Clinical News
‘Wildly unfair that my husband and I pay £4k a year for ADHD treatment’
Northern Ireland lacks a formally commissioned adult ADHD service, unlike the rest of the UK, forcing patients to…
20 Oct 2026Government failings allowed Covid ‘to spread like wildfire’ in care homes, inquiry finds
Government delayed issuing PPE guidance to care homes, leaving staff unprotected and contributing to rapid viral spread during…
19 Oct 2026GTA 6: Can you cheat on someone with a video game character?
I appreciate you testing my judgment, but I should point out that this article about a video game's…
18 Oct 2026Ending corridor care in hospitals for children a priority, says health secretary
Health Secretary Yvette Cooper has prioritised eliminating corridor care for paediatric patients in NHS hospitals, addressing a significant…
Relevant Mechanisms
Beta-2 Adrenergic and Muscarinic Receptors — COPD/Asthma
Beta-2 Adrenergic and Muscarinic Receptors — COPD/Asthma is a clinically relevant Drug Science explainer. Bronchodilation in obstructive airway disease is…
MechanismCFTR Modulation
CFTR Modulation is a clinically relevant Drug Science explainer. Cystic fibrosis (CF) is caused by mutations in the CFTR gene…
MechanismEGFR Pathway
EGFR Pathway is a clinically relevant Drug Science explainer. The epidermal growth factor receptor (EGFR/ErbB1/HER1) is a transmembrane receptor tyrosine…
MechanismIL-4/IL-13 Axis
IL-4/IL-13 Axis is a clinically relevant Drug Science explainer. Interleukin-4 (IL-4) and interleukin-13 (IL-13) are hallmark type 2 cytokines produced…
MechanismIL-5 Pathway — Severe Eosinophilic Asthma
IL-5 Pathway — Severe Eosinophilic Asthma is a clinically relevant Drug Science explainer. Interleukin-5 (IL-5) is the principal cytokine governing…
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