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MHRA • NHS England • NICE • UKHSA

Clinical News & Alerts

379+ sourced updates — safety alerts, regulatory decisions and NHS England announcements, verified for UK clinicians.

MHRA Safety Alert NHS England NICE Update UKHSA
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Clinical News

Latest Alerts & Updates

⚠️ Safety Alert
MHRA
Valproate use in men: as a precaution, men and their partners should use effective contraception
A retrospective observational study has indicated a possible association between valproate use by men around the time of conception and an increased…
05 Sep 2024 View brief →
⚠️ Safety Alert
MHRA
Yellow Card Biobank: call to contribute to study of genetic links to side effects
Support this initiative to explore whether there is a genetic basis of side effects associated with direct-acting oral anticoagulants (DOACs) and allopurinol.…
21 Aug 2024 View brief →
⚠️ Safety Alert
MHRA
Letters and medicine recalls sent to healthcare professionals in July 2024
A summary of recent letters and notifications sent to healthcare professionals about medicines and medical devices. This update is best treated as…
21 Aug 2024 View brief →
⚠️ Safety Alert
MHRA
Epimax Ointment and Epimax Paraffin-Free Ointment: reports of ocular surface toxicity and ocular chemical injury
Epimax Ointment and Epimax Paraffin-Free Ointment can harm the eyes if used on the face. Do not prescribe these ointments for use…
23 Jul 2024 View brief →
⚠️ Safety Alert
MHRA
Letters and medicine recalls sent to healthcare professionals in June 2024
A summary of recent letters and notifications sent to healthcare professionals about medicines and medical devices. This update is best treated as…
23 Jul 2024 View brief →
⚠️ Safety Alert
MHRA Women's Health
Topiramate (Topamax): introduction of new safety measures, including a Pregnancy Prevention Programme
Topiramate is now contraindicated in pregnancy and in women of childbearing potential unless the conditions of a Pregnancy Prevention Programme are fulfilled.…
20 Jun 2024 View brief →
⚠️ Safety Alert
MHRA
Warfarin: be alert to the risk of drug interactions with tramadol
Taking warfarin and tramadol together can cause harmful drug interactions, which can raise the International Normalised Ratio (INR), and result in severe…
20 Jun 2024 View brief →
⚠️ Safety Alert
MHRA
Letters and medicine recalls sent to healthcare professionals in May 2024
A summary of recent letters and notifications sent to healthcare professionals about medicines and medical devices. This update is best treated as…
20 Jun 2024 View brief →
⚠️ Safety Alert
MHRA Dermatology
Topical steroids: introduction of new labelling and a reminder of the possibility of severe side effects, including Topical Steroid Withdrawal Reactions
Topical steroid products are safe and highly effective treatments for the management of a wide range of inflammatory skin diseases but have…
29 May 2024 View brief →
⚠️ Safety Alert
MHRA
Letters and medicine recalls sent to healthcare professionals in April 2024
A summary of recent letters and notifications sent to healthcare professionals about medicines and medical devices, and information about the publication of…
29 May 2024 View brief →