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MHRA • NHS England • NICE • UKHSA

Clinical News & Alerts

225+ sourced updates — safety alerts, regulatory decisions and NHS England announcements, verified for UK clinicians.

MHRA Safety Alert NHS England NICE Update UKHSA
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Clinical News

Latest Alerts & Updates

⚠️ Safety Alert
MHRA Diabetes / Metabolic
Falsified Mounjaro KwikPen 15mg pre-filled pens
A falsified version of Mounjaro (tirzepatide) KwikPen 15mg solution for injection has been found supplied through one online pharmacy in the UK.…
24 Feb 2026 View brief →
⚠️ Safety Alert
MHRA Infectious Disease
IXCHIQ Chikungunya vaccine: temporary suspension in people aged 65 years or older
The Commission on Human Medicines (CHM) has temporarily restricted use of the IXCHIQ Chikungunya vaccine in people aged 65 years and over…
11 Feb 2026 View brief →
⚠️ Safety Alert
MHRA Infectious Disease
IXCHIQ Chikungunya vaccine: updates to restrictions of use following safety review
IXCHIQ Chikungunya vaccine: updates to restrictions of use following safety revi...
11 Feb 2026 View brief →
⚠️ Safety Alert
MHRA Diabetes / Metabolic
Semaglutide (Wegovy, Ozempic and Rybelsus): risk of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
Semaglutide (Wegovy, Ozempic and Rybelsus): risk of Non-arteritic Anterior Ische...
05 Feb 2026 View brief →
⚠️ Safety Alert
MHRA Diabetes / Metabolic
GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists: strengthened warnings on acute pancreatitis, including necrotising and fatal cases
GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists: strengthened warni...
29 Jan 2026 View brief →
⚠️ Safety Alert
MHRA
Isotretinoin – changes to prescribing guidance and additional risk minimisation measures
The Commission on Human Medicines (CHM) has endorsed changes to the risk minimisation measures for isotretinoin, following a review of the impact…
22 Jan 2026 View brief →
⚠️ Safety Alert
MHRA Mental Health / Psychiatry
Improving Information Supplied with Gabapentinoids (Pregabalin/Gabapentin), Benzodiazepines and Z-Drugs
The MHRA has reviewed the warnings regarding addiction, dependence, withdrawal, and tolerance for gabapentin, pregabalin, benzodiazepines, and z-drugs. The findings (detailed in…
08 Jan 2026 View brief →
⚠️ Safety Alert
MHRA Diabetes / Metabolic
Rybelsus ® (semaglutide tablets): transition to new formulation and risk of medication error
Rybelsus ® (semaglutide tablets): transition to new formulation and risk of med...
17 Dec 2025 View brief →
⚠️ Safety Alert
MHRA Cardiology / Cardiovascular
Mesalazine and idiopathic intracranial hypertension
Idiopathic intracranial hypertension (IIH) has been very rarely reported in patients treated with mesalazine. Following a recent review, warnings for IIH are…
04 Dec 2025 View brief →
⚠️ Safety Alert
MHRA Dermatology
Isotretinoin – updates to prescribing guidance and survey of services
The Commission on Human Medicines (CHM) has endorsed changes to isotretinoin prescribing guidance. In addition, CHM is seeking further information from dermatology…
27 Oct 2025 View brief →