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MHRA • NHS England • NICE • UKHSA

Clinical News & Alerts

225+ sourced updates — safety alerts, regulatory decisions and NHS England announcements, verified for UK clinicians.

MHRA Safety Alert NHS England NICE Update UKHSA
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Clinical News

Latest Alerts & Updates

⚠️ Safety Alert
MHRA
#MedSafetyWeek (3-9 November 2025): A call to action to improve patient safety
The annual #MedSafetyWeek campaign takes place from 3 to 9 November 2025. This year’s campaign theme is ‘we can all help make…
23 Oct 2025 View brief →
⚠️ Safety Alert
MHRA Women's Health
Paracetamol and pregnancy – reminder that taking paracetamol during pregnancy remains safe
Patients should be reminded and reassured that there is no evidence that taking paracetamol during pregnancy causes autism in children. Paracetamol is…
23 Sep 2025 View brief →
⚠️ Safety Alert
MHRA Infectious Disease
Abrysvo▼ (Pfizer RSV vaccine) and Arexvy▼ (GSK RSV vaccine): be alert to a small risk of Guillain-Barré syndrome following vaccination in older adults
There is a small increase in the risk of Guillain-Barré syndrome following vaccination with Abrysvo (Pfizer respiratory syncytial virus (RSV) vaccine) and…
07 Jul 2025 View brief →
⚠️ Safety Alert
MHRA
Valproate (Belvo, Convulex, Depakote, Dyzantil, Epilim, Epilim Chrono or Chronosphere, Episenta, Epival, and Syonell▼): updated safety and educational materials to support patient discussion on reproductive risks
Updated safety and educational materials are now available to support the implementation of the regulatory measures announced in the November 2023 National…
10 Jun 2025 View brief →
⚠️ Safety Alert
MHRA Women's Health
Thiopurines and intrahepatic cholestasis of pregnancy
Thiopurines and intrahepatic cholestasis of pregnancy
15 May 2025 View brief →
⚠️ Safety Alert
MHRA Mental Health / Psychiatry
Kaftrio▼ (Ivacaftor, tezacaftor, elexacaftor): risk of psychological side effects
Psychological side effects such as anxiety, low mood, sleep disturbance, poor concentration, and forgetfulness have been infrequently reported in people with cystic…
07 May 2025 View brief →
⚠️ Safety Alert
MHRA Respiratory / COPD / Asthma
Short-acting beta 2 agonists (SABA) (salbutamol and terbutaline): reminder of the risks from overuse in asthma and to be aware of changes in the SABA prescribing guidelines
Healthcare professionals and patients are reminded of the risk of severe asthma attacks and increased mortality associated with overuse of SABA with…
24 Apr 2025 View brief →
⚠️ Safety Alert
MHRA Gastroenterology
Fezolinetant▼(Veoza): risk of liver injury; new recommendations to minimise risk
Fezolinetant treatment is associated with a risk of drug induced liver injury. New recommendations have been introduced to minimise this risk. Liver…
10 Apr 2025 View brief →
⚠️ Safety Alert
MHRA
Prolonged-release opioids: Removal of indication for relief of post-operative pain
Prolonged-release opioids: Removal of indication for relief of post-operative pa...
12 Mar 2025 View brief →
⚠️ Safety Alert
MHRA
Letters and medicine recalls sent to healthcare professionals in January 2025
A summary of recent letters and notifications sent to healthcare professionals about medicines and medical devices.  This update is best treated as…
26 Feb 2025 View brief →