Why caffeine makes some people buzz

• Caffeine sensitivity is determined by a combination of genetic factors, habitual caffeine use, and lifestyle—not just consumption frequency alone
• Individual genetic variation means some people metabolise caffeine efficiently whilst others experience prolonged effects, explaining variable responses to the same dose
• Clinicians should consider patient genetics and lifestyle when advising on caffeine intake, particularly for those reporting anxiety, sleep disturbance, or cardiac symptoms

Scientists say it all depend on caffeine habits, lifestyle and one factor we have no control over: our genes.

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