Women hit fertility tipping point at 49 – even with young donor eggs

• Women's fertility declines significantly after age 49 regardless of egg quality, suggesting age-related uterine changes rather than ovarian reserve alone limits conception
• Endometrial dysfunction appears to be the limiting factor in older women undergoing fertility treatment, even when using young donor eggs
• Future interventions targeting age-related changes in the womb lining could potentially extend the reproductive window for older women seeking fertility treatment

Age-related changes in the womb lining may be the cause and could be treatable in the future, say experts.

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