ClinicaliQ Trial Snapshot
- A Study of GDC-9545 Alone or in Combination With Palbociclib and/or Luteinizing Hormone-Releasing Hormone (LHRH) Agonist in Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer — Active Not Recruiting • Phase I • Oncology • NCT03332797.
- Trial of new hormone therapy GDC-9545 alone or combined with existing drugs for advanced oestrogen receptor-positive breast cancer.
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What This Trial Is Studying
This study will evaluate the safety, pharmacokinetic (PK), pharmacodynamic (PD) activity, and preliminary anti-tumor activity of GDC-9545 as a single agent and in combination with palbociclib and/or luteinizing hormone-releasing hormone (LHRH) agonist in participants with advanced or metastatic estrogen receptor (ER)-positive (human epidermal growth factor receptor 2 [HER2]-negative) breast cancer. Conditions: Breast Cancer Interventions: GDC-9545, Palbociclib, LHRH Agonist Lead Sponsor: Genentech, Inc. Planned Enrollment: 181 participants