- A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease — Recruiting • Phase I • Cardiology / Cardiovascular • NCT06164730.
- VT-10201 is an Open-label, Phase 1b, Single-ascending Dose Study That Will Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia (HeFH) or Premature Coronary Artery Disease (CAD) Who Require Additional Lowering of LDL-C. VERVE-102 Uses Base-editing Technology Designed to….
- Sponsor: Verve Therapeutics, Inc.
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VT-10201 is an Open-label, Phase 1b, Single-ascending Dose Study That Will Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia (HeFH) or Premature Coronary Artery Disease (CAD) Who Require Additional Lowering of LDL-C. VERVE-102 Uses Base-editing Technology Designed to Disrupt the Expression of the PCSK9 Gene in the Liver and Lower Circulating PCSK9 and LDL-C. This Study is Designed to Determine the Safety and Pharmacodynamic Profile of VERVE-102 in This Patient Population. Lead Sponsor: Verve Therapeutics, Inc. Start Date: 2024-04-30 Primary Completion: 2026-08
- : * Diagnosis of HeFH or premature CAD
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