ClinicaliQ Trial Snapshot
- A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL) — Recruiting • Phase III • Oncology • NCT06428019.
- What is being tested: Safety and risk of tumor lysis syndrome (TLS) in treatment-Phase IIIïve adults with CLL receiving venetoclax combined with either intravenous obinutuzumab or oral acalabrutinib.
- Patient eligibility overview: Adults with previously untreated chronic lymphocytic leukemia eligible for these dual-therapy combinations, with assessment of adverse events and clinical outcomes during treatment.
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- Quick orientation before opening the registry record.
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What This Trial Is Studying
Chronic lymphocytic leukemia (CLL) is the most common leukemia (cancer of blood cells). The purpose of this study is to assess the safety of venetoclax in combination with obinutuzumab or acalabrutinib in the treatment of CLL. Adverse events and change in disease activity will be assessed. Venetoclax in combination with obinutuzumab or acalabrutinib is being investigated in the treatment of CLL. Study doctors put the participants in 1 of 4 groups, called treatment arms. Participants will receive oral venetoclax in combination with intravenously (IV) infused obinutuzumab or oral acalabrutinib at…
Eligibility Snapshot
- : * Diagnosis of documented, previously untreated, chronic lymphocytic leukemia (CLL) requiring treatment according to the 2018 international workshop on chronic lymphocytic leukemia (iwCLL) criteria and have a life expectancy of > 6 months. * Previously untreated small lymphocytic lymphoma (SLL) meeting the 2018 iwCLL criteria for treatment will also be equally considered as CLL for eligibility, screening, treatment and evaluation. * Eastern Cooperative Oncology Group (ECOG) performance status = 30 mL/min using the Cockcroft-Gault formula are eligible for inclusion.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.