Oncology Cardiology / Cardiovascular Respiratory / COPD / Asthma Infectious Disease Gastroenterology Diabetes / Metabolic Neurology Rheumatology Women's Health Mental Health / Psychiatry Dermatology Rare Diseases Men's Health
Clinical Trial ● Currently Recruiting Phase II NCT06977581

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma — Recruiting • Phase II • Respiratory / COPD / Asthma • NCT06977581.

📅 04 May 2026 ⏱ 2 min read
Currently Recruiting
This trial is actively seeking participants in the UK. Discuss eligibility with your patient before referring.
Status
Currently Recruiting
Phase
Phase II
NCT ID
NCT06977581
Sponsor
Pfizer
Start
2025-05-20
ClinicaliQ Trial Snapshot
  • A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma — Recruiting • Phase II • Respiratory / COPD / Asthma • NCT06977581.
  • Treatment being tested: PF-07275315, an investigational medicine for moderate-to-severe asthma, with assessment of its safety profile and clinical efficacy in reducing breathing difficulties.
  • Patient eligibility: Adults with confirmed moderate-to-severe asthma diagnosis; typically requires documented airway obstruction, suboptimal control on current therapy, and absence of significant comorbidities that would compromise trial safety.
Use This Page For
  • Quick orientation before opening the registry record.
  • Checking recruitment status, phase and sponsor at a glance.
  • Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying

The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 18 to 70 years old * Have had moderate-to-severe asthma for at least 12 months that is not well controlled * Have been taking their regular maintenance treatment(s) for asthma over…

Eligibility Snapshot
  • : Must meet the following asthma criteria: 1. History of persistent, moderate-to-severe asthma for at least 12 months prior to screening. 2. Must have experienced at least 1 asthma exacerbation requiring treatment with systemic steroids (oral or parenteral) for 3 days or more within 12 months of the screening visit. 3. At least 2 of the 3 pre-bronchodilator FEV1 values collected in the run-in period and the mean of the of pre-bronchodilator FEV1 values collected in the run-in period are ≥30% to

Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.

Full Trial Details
View this trial on the source registry
Eligibility criteria, protocol, and results when available
View Trial ↗
Share: Twitter/X LinkedIn
Related

Related Clinical Intelligence

Guidelines, Drug Science, safety briefs and education connected to this trial area.

Clinical Brief
Amiodarone: reminder of risks of treatment and need for patient monitoring and supervision
Respiratory / COPD / Asthma · MHRA · 20 May 2026
Amiodarone carries serious risks of pulmonary, hepatic, and thyroid toxicity requiring regular patient monitoring and supervision throughout treatment Healthcare professionals must ensure…
View brief →
Guideline
Mepolizumab for maintenance treatment of uncontrolled chronic obstructive pulmonary disease with raised blood eosinophils
Respiratory / COPD / Asthma · 17 Jun 2026
Mepolizumab is recommended for patients with uncontrolled COPD and blood eosinophils ≥100 cells/μL; check eosinophil levels before initiating treatment as this is…
View guideline →
Guideline
UK Achondroplasia Network’s consensus guideline for multidisciplinary care of children and young people with achondroplasia: NICE review
Respiratory / COPD / Asthma · 19 May 2026
Establish multidisciplinary team review at diagnosis and at key developmental stages (infancy, pre-school, school age, adolescence) to monitor for complications including spinal…
View guideline →
Guideline
Brensocatib for treating non-cystic fibrosis bronchiectasis in people 12 years and over (terminated evaluation)
Respiratory / COPD / Asthma · 25 Aug 2026
Evaluation terminated: Brensocatib for non-CF bronchiectasis is no longer under NICE appraisal—do not initiate new treatment pathways for this indication pending alternative…
View guideline →
Clinical Brief
Amiodarone: reminder of risks of treatment and need for patient monitoring and supervision
Respiratory / COPD / Asthma · MHRA · 20 May 2026
Amiodarone carries serious risks of pulmonary, hepatic, and thyroid toxicity requiring baseline assessment and regular monitoring throughout treatment Patients on amiodarone require…
View brief →
Clinical Brief
AI sleep data could provide one-week early warning of flu and COVID-19
Respiratory / COPD / Asthma · UKHSA · 03 Sep 2026
Sleep-tracking apps analysing cough patterns can detect flu and COVID-19 approximately one week before symptom onset, potentially enabling early intervention and isolation…
View brief →