- Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics — Active Not Recruiting • Phase IV • Respiratory / COPD / Asthma • NCT03953300.
- Benralizumab improves lung structure and function in severe eosinophilic asthma poorly controlled by standard inhalers.
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The purpose of the study is to evaluate effect of benralizumab on structural and lung function changes in severe eosinophilic asthmatics. Changes will be assessed over 48 week treatment period in patients with persistent symptoms despite standard therapy of inhaled corticosteroids (ICS) plus long acting B2-agonist (LABA) with or without additional controller medication. Patients who complete treatment will enter 4 weeks follow-up period. Conditions: Asthma Interventions: Benralizumab, Placebo Lead Sponsor: AstraZeneca Planned Enrollment: 75 participants