- Closed-loop TMS for Tremor — Recruiting • Non-phase study • Neurology • NCT07574164.
- Phase-locked brain stimulation may reduce tremor in essential tremor and Parkinson's disease patients when timed to suppress tremor cycles.
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This study investigates the potential of phase-locked transcranial magnetic stimulation (TMS) as a non-invasive intervention for tremor in patients with Essential Tremor (ET) and Parkinson's Disease (PD). Tremor is a prevalent symptom that significantly impacts physical function and social participation. ET affects approximately 1% of the global population and worsens with age, while PD tremor is often less responsive to conventional dopaminergic therapy. Current treatments, including oral medications (propranolol, primidone), anticholinergics, and deep brain stimulation (DBS), are either limited by efficacy, side effects, or invasiveness. These challenges highlight the need…