ClinicaliQ Trial Snapshot
- Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE) — Recruiting • Non-phase study • Cardiology / Cardiovascular • NCT07579390.
- What is being tested: STEPCARE-MAKE evaluates how three interventions—sedation strategies, temperature management, and blood pressure targets—affect acute kidney injury (MAKE) outcomes in comatose survivors of out-of-hospital cardiac arrest across 3,500 patients.
- Patient eligibility overview: The study includes comatose adult patients successfully resuscitated from out-of-hospital cardiac arrest who are enrolled in the main STEPCARE trial, representing a broad post-resuscitation population requiring intensive care management.
Use This Page For
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying
The STEPCARE-MAKE study is a predefined prospective sub-study of the 2x2x2 factorial STEPCARE trial, which evaluates the effects of three interventions in comatose adult patients resuscitated from out-of-hospital cardiac arrest. In this sub-study, all 3500 participants enrolled in the main trial are assessed for major adverse kidney events (MAKE) and creatinine kinetics.
Eligibility Snapshot
- : * All patients included to the main STEPCARE-trial are also included to this substudy * Out-of-hospital cardiac arrest * Sustained return of spontaneous circulation, defined as 20 minutes with signs of circulation without the need for chest compressions * Unconsciousness (FOUR-score motor response
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.