ClinicaliQ Trial Snapshot
- Health Impact of Non-Tuberculous Mycobacteria Pulmonary Disease (NTM-PD) — Recruiting • Respiratory / COPD / Asthma • NCT07192705.
- What is being tested: The health impact and disease burden of non-tuberculous mycobacteria pulmonary disease (NTM-PD), an environmental infection caused by organisms found in soil and water that primarily affects individuals with pre-existing chronic lung conditions.
- Patient eligibility overview: The trial focuses on patients with chronic lung disease (such as COPD) who have developed or are at risk of developing NTM pulmonary infection, representing a vulnerable population with underlying respiratory compromise.
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- Quick orientation before opening the registry record.
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What This Trial Is Studying
Nontuberculous mycobacteria (NTM) are environmental organisms found in soil and water. The majority do not cause human disease. When they do, this is mostly as a chronic lung infection in people with long-term lung problems such as chronic obstructive pulmonary disease (COPD), bronchiectasis, or cystic fibrosis. The number of people with NTM pulmonary disease (PD) is increasing, and its management can be complex, requiring prolonged treatment with multiple, often toxic, drugs in someone who may already be frail. Non-drug approaches, such as airway clearance techniques, structured exercise, nutritional support and…
Eligibility Snapshot
- : - Age: 18 years or older, able to provide informed consent. NTM-PD Group: * Participants will be adults diagnosed with confirmed NTM-PD based on the British Thoracic Society (BTS) guidelines. * The participant should not be on any antimicrobial therapy (at least two weeks before participation) and should not have previously received or be currently on antimicrobial therapy for NTM-PD. * BTS guidelines: * Clinical (both required): * Pulmonary symptoms, nodular or cavitary opacities on chest radiograph, or a high-resolution CT scan that shows multifocal bronchiectasis with multiple small nodules. * Appropriate exclusion of other diagnoses. * Microbiological: * A minimum of two positive expectorated sputum culture results of the same NTM species from samples collected on separate days within 12 months before recruitment. OR * Positive culture results from at least one bronchial wash or lavage. OR * Transbronchial or other lung biopsy with mycobacterial histopathological features (granulomatous inflammation or AFB) and positive culture for NTM or biopsy showing mycobacterial histopathological features (granulomatous inflammation or AFB) and one or more sputum or bronchial washings that are culture-positive for NTM. Bronchiectasis Group: * Diagnosed with bronchiectasis, as confirmed in medical records based on clinical assessment, and radiological findings.…
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.