ClinicaliQ Trial Snapshot
- Influence of NEP Inhibition on Vascular Leak and Inflammation (NEPi-INFLAMMATION) — Active Not Recruiting • Non-phase study • Respiratory / COPD / Asthma • NCT05600062.
- Testing whether a drug that increases C-type natriuretic peptide levels reduces fluid leak in experimental skin blisters, as a potential treatment for severe lung injury.
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What This Trial Is Studying
Acute Respiratory Distress Syndrome (ARDS) is a severe type of lung injury that affects 10% of patients admitted to Intensive Care Units worldwide, with an unacceptably high mortality of up to 48% in those with the most severe form of the condition. It is a complex and poorly understood syndrome that results in progressive failure of the lungs. Crucially, the inflamed lungs allow fluid to leak from the circulation into the airspace, so that patients' lungs fill with fluid - "drowning from the inside". As this condition progresses, the patient…