ClinicaliQ Trial Snapshot
- Methods of T Cell Depletion Trial (MoTD) — Recruiting • Phase II • Cardiology / Cardiovascular • NCT04888741.
- What is being tested: Three different GvHD prophylaxis strategies following unrelated donor stem cell transplantation: Thymoglobulin, calcineurin inhibitor-based regimens, and sirolimus-based post-transplant cyclophosphamide approaches.
- Patient eligibility overview: Adults and children requiring unrelated donor haematopoietic stem cell transplantation who are suitable candidates for one of the three GvHD prophylaxis strategies being compared in this multi-centre trial.
Use This Page For
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
What This Trial Is Studying
A multi-centre phase II trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin vs. Calcineurin inhibitor or Sirolimus-based post-transplant cyclophosphamide.
Eligibility Snapshot
- : * Availability of suitably matched unrelated donor (9/10 or 10/10) * Planned to receive one of the following RIC protocols: * Fludarabine-Melphalan (Fludarabine 120-180mg/m2 IV; melphalan ≤ 150mg/m2 IV) * BEAM or LEAM (carmustine 300mg/m2 IV or lomustine 200mg/m2 IV with: etoposide 800 mg/m2 IV; cytarabine 1600mg/m2 IV; melphalan 140mg/m2 IV) * Fludarabine-Busulphan (Fludarabine 120-180mg/m2 IV; Busulphan ≤ 8mg/kg PO or 6.4mg/kg IV) * Fludarabine- Treosulfan (Fludarabine 150mg/m2 IV; Treosulfan 30g/m2 IV) * Planned use of PBSCs for transplantation * Planned allo-SCT for one of the following haematological malignancies: * AML in CR (patients enrolled onto the COSI trial are not eligible for this study) * ALL in CR (patients enrolled onto the ALL-RIC trial are not eligible for this study) * CMML
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.