- Physical Activity Promotion and Clinical Remission in Severe Asthma — Recruiting • Non-phase study • Respiratory / COPD / Asthma • NCT07735494.
- What is being tested: A structured physical activity promotion programme combined with tezepelumab (a biologic therapy) versus standard care alone, to determine if exercise intervention enhances clinical remission rates in adults with severe asthma.
- Patient eligibility overview: Adults with severe asthma who are candidates for tezepelumab treatment; this targets patients with difficult-to-control disease despite optimised conventional therapy and other biologic options.
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
This study will investigate whether a structured physical activity promotion programme, delivered alongside standard treatment with tezepelumab, increases the proportion of adults with severe asthma achieving clinical remission compared with standard care alone. Although biologic therapies have improved asthma control for many people with severe asthma, many individuals remain physically inactive, experience reduced exercise tolerance, and continue to report symptoms that affect their quality of life. Physical inactivity may represent a modifiable factor that limits the achievement of optimal health outcomes. Adults with severe asthma who are starting tezepelumab as…
- : * Adults aged 18-70 years. * Physician-diagnosed severe asthma. * Eligible for tezepelumab according to NICE TA880. * History of ≥3 asthma exacerbations requiring oral corticosteroids in the previous 12 months or receiving maintenance oral corticosteroid therapy. * Objective confirmation of asthma, including bronchodilator reversibility, bronchial hyperresponsiveness and/or variable airflow obstruction, as part of routine clinical assessment. * Decision to commence tezepelumab made by the treating multidisciplinary severe asthma team prior to study enrolment. * Able and willing to provide written informed consent.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.