- Selecting Hypoxic Tumours for Treatment Modification — Recruiting • Oncology • NCT06787053.
- What is being tested: Methods to identify and select patients with hypoxic solid tumours for treatment intensification strategies, since hypoxic tumours demonstrate reduced radiotherapy responsiveness compared to normoxic tumours.
- Patient eligibility overview: Solid tumour patients scheduled for radiotherapy, with particular focus on the >25% of this population with hypoxic tumours, who currently have poor treatment outcomes with standard radiotherapy alone.
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
Approximately 50% of cancer patients with solid tumours will be treated with radiotherapy. A significant proportion (>25%) of patients have hypoxic tumours which respond poorly to radiotherapy. Hypoxic tumours have a poor prognosis. This can be improved with treatment intensification. Treatment intensification can be modification with CON (breathing O2-enriched air + oral administration of nicotinamide), chemoradiosensitisation, radiation dose-escalation or additional systemic treatments, significantly improving response of the tumours to radiotherapy. However, there are currently no clinically approved biomarkers to identify hypoxic tumours. Our group has developed and validated gene-expression signature-based…
- : This will be tumour site dependent. Bladder: * Older than age 18 years. * Patients having radiotherapy at the Christie NHS Foundation Trust suitable for imaging on an MRI scanner. * Able to give informed consent. Cervix: * Older than age 18 years. * Patients having radiotherapy at the Christie NHS Foundation Trust suitable for imaging on an MRI scanner. * Able to give informed consent. Prostate: * Older than age 18 years. * Patients having radiotherapy at the Christie NHS Foundation Trust suitable for imaging on an MRI scanner. * Able to give informed consent.
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.