- Using Multiomics to Define Mechanisms of Rhinovirus-induced Chronic Obstructive Pulmonary Disease Exacerbations to Develop Novel Therapies and Therapeutic Targets — Recruiting • Respiratory / COPD / Asthma • NCT07112235.
- Sponsor: Imperial College London.
Verify eligibility, endpoints and current status on the original source registry before acting on this summary.
- Quick orientation before opening the registry record.
- Checking recruitment status, phase and sponsor at a glance.
- Connecting this trial to nearby guidelines, Drug Science and education.
The goal of this study is to examine exacerbations of chronic obstructive pulmonary disease (COPD) caused by a common cold virus called rhinovirus, to identify new treatments. Exacerbations are flare-ups of respiratory symptoms which are a major cause of ill health in people with COPD, and are most commonly caused by viruses. The main questions the study aims to answer are: * What processes in the body occur in response to rhinovirus infection, and do the differences between people with COPD and healthy volunteers explain why people with COPD develop…
- for COPD subjects * Male or female sex * Age ≥40 years and ≤75 years at the time of signing the consent form * Medical history or clinical diagnosis of COPD * Significant smoking history, defined as: * Cumulative smoking history of at least 20 pack years * Permitted to currently use, or have history of use of, e-cigarettes/vapes * COPD spirometry criteria: * Post bronchodilator FEV1 of
Use the source registry for the full inclusion and exclusion criteria before discussing referral or enrolment.