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SGLT2 Inhibitors: From Glycaemia to Heart Failure and Chronic Kidney Disease

SGLT2 inhibitors started as diabetes drugs and became some of the most important medicines in cardiology and nephrology. Dr Anzal Qurbain covers the mechanism, the landmark DAPA-HF, EMPEROR-Reduced, a

🎓 Dr Anzal Qurbain 📅 3 April 2026 ⏰ 00:14:06
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This on-demand webinar is a recorded episode from the Drug Class Explainers series.
Listen to the full session below and earn 0.5 CPD hours upon completion.

SGLT2 inhibitors started as diabetes drugs and became some of the most important medicines in cardiology and nephrology. Dr Anzal Qurbain covers the mechanism, the landmark DAPA-HF, EMPEROR-Reduced, and DAPA-CKD trials, and the critical sick day rules every clinician must know — including the risk of euglycaemic DKA.

Use the slide outline alongside the recording for a structured review of the session.

SGLT2 inhibitors — session overview

  • From glucose lowering to cardio-renal protection
  • Why renal physiology explains the broader clinical effects
  • Diabetes, heart failure and CKD as overlapping care pathways

Proximal tubule mechanism

  • SGLT2 reabsorbs filtered glucose and sodium in the proximal tubule
  • Inhibition produces glucosuria and natriuresis
  • Downstream effects include osmotic diuresis and altered tubuloglomerular feedback

Heart failure relevance

  • Clinical value extends beyond HbA1c lowering
  • Volume, haemodynamic and renal mechanisms may contribute to benefit
  • Practical implications for multi-morbidity and polypharmacy review

CKD relevance

  • Tubuloglomerular feedback and intraglomerular pressure concepts
  • Albuminuria, eGFR and renal trajectory as monitoring themes
  • Use within current CKD and cardio-renal guidance pathways

Safety and counselling

  • Genital mycotic infections and hydration advice
  • Sick-day rules and ketoacidosis risk discussion
  • Review renal function, concomitant diuretics and acute illness context

Clinical takeaways

  • SGLT2 inhibitors are now cardio-renal medicines as well as diabetes medicines
  • Patient selection and counselling are central to safe use
  • Keep educational mechanism discussion separate from product-specific promotion
🎓
Dr Anzal Qurbain
Specialist Speaker
00:14:06
0.5 — UK CPD accredited
📅3 April 2026
🎓Dr Anzal Qurbain
🌐Watch on demand, online
Diabetes / Metabolic
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