Gastroenterology
Gastroenterology guidance, inflammatory bowel disease mechanisms, trial updates and education for clinicians following digestive disease evidence.
Latest Guidelines
Ex-situ machine perfusion devices to preserve deceased donor livers for transplantation
Consider ex-situ machine perfusion as an alternative to static cold storage for deceased donor livers, particularly for higher-risk grafts (extended criteria donors, prolonged cold ischaemia time)…
2022 ESPGHAN Guidelines on Coeliac Disease Diagnosis
This ESPGHAN guideline addresses 2022 ESPGHAN Guidelines on Coeliac Disease Diagnosis in Gastroenterology. Use it to review current recommendation wording, eligibility criteria, and implementation considerations in…
2023 EASL Clinical Practice Guidelines on Cirrhosis
This EASL guideline addresses 2023 EASL Clinical Practice Guidelines on Cirrhosis in Gastroenterology. Use it to review current recommendation wording, eligibility criteria, and implementation considerations in…
2023 EASL-EASD-EASO Clinical Practice Guidelines for MASLD
This EASL guideline addresses 2023 EASL-EASD-EASO Clinical Practice Guidelines for MASLD in Gastroenterology. Use it to review current recommendation wording, eligibility criteria, and implementation considerations in…
2022 EASL Clinical Practice Guidelines on Hepatitis C
This EASL guideline addresses 2022 EASL Clinical Practice Guidelines on Hepatitis C in Gastroenterology. Use it to review current recommendation wording, eligibility criteria, and implementation considerations…
Pancreatitis (NICE NG104)
Confirm acute pancreatitis diagnosis using serum lipase (or amylase if unavailable) with characteristic clinical features; perform baseline assessment including FBC, U&Es, LFTs, glucose, calcium, CRP and…
Trial Radar
A Clinical Study to Assess Safety, Efficacy and Pharmacodynamic Profile of GNT0004 in Duchenne Muscular Dystrophy
GNT0004 is a one-time gene therapy delivering a functional dystrophin gene to slow Duchenne muscular dystrophy progression.
PHASE2Study to Evaluate the Efficacy, Safety and Tolerability of MAS825 in Patients With Monogenic IL-18 Driven Autoinflammatory Diseases, Including NLRC4-GOF, XIAP Deficiency, or CDC42 Mutations
MAS825 tested as treatment for rare genetic inflammatory disorders caused by NLRC4, XIAP, or CDC42 mutations.
PHASE3A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
Trial testing linvoseltamab alone or with carfilzomib versus standard treatments in patients with relapsed/refractory myeloma after 1-3 prior…
PHASE3A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangitis
Elafibranor versus placebo for primary sclerosing cholangitis: a trial assessing efficacy and safety in 350 adults over five…
Clinical News
NHS staff investigated over access to dead teenager’s medical records
NHS staff in Bristol are under investigation for potentially unauthorised access to deceased patient Oliver McGowan's medical records…
17 Sep 2026‘Inspirational’ 97-year- old wing walker gives back to hospital ward
A 97-year-old patient demonstrated remarkable recovery and engagement post-treatment, highlighting potential for active rehabilitation and positive psychological outcomes…
26 Aug 2026Mum’s perforated bowel ordeal after scan error
A patient developed life-threatening sepsis secondary to a perforated bowel that was missed on imaging during the postnatal…
10 Aug 2026England set to eliminate hepatitis C
Hepatitis C Elimination in England England is progressing toward hepatitis C elimination, positioning itself among the world's first…
Relevant Mechanisms
Alpha-4-Beta-7 Integrin — Gut-selective Lymphocyte Trafficking
Alpha-4-Beta-7 Integrin — Gut-selective Lymphocyte Trafficking is a clinically relevant Drug Science explainer. Lymphocyte trafficking to the intestinal mucosa is…
MechanismCFTR Modulation
CFTR Modulation is a clinically relevant Drug Science explainer. Cystic fibrosis (CF) is caused by mutations in the CFTR gene…
MechanismJAK-STAT Pathway
JAK-STAT Pathway is a clinically relevant Drug Science explainer. The Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway is…
MechanismS1P Receptor Modulation — MS/IBD
S1P Receptor Modulation — MS/IBD is a clinically relevant Drug Science explainer. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite generated…
MechanismThe IL-17/IL-23 Axis
The IL-17/IL-23 Axis is a clinically relevant Drug Science explainer. The IL-23/IL-17 axis is a central driver of immune-mediated inflammatory…
CPD, Podcasts & Webinars
No specialty-tagged education live yet
Gastroenterology podcasts, webinars and CPD modules will appear here as new education is published and tagged.
Useful starting points in Gastroenterology
A Clinical Study to Assess Safety, Efficacy and Pharmacodynamic Profile of GNT0004 in Duchenne Muscular Dystrophy
GNT0004 is a one-time gene therapy delivering a functional dystrophin gene to slow Duchenne muscular dystrophy progression.
TrialStudy to Evaluate the Efficacy, Safety and Tolerability of MAS825 in Patients With Monogenic IL-18 Driven Autoinflammatory Diseases, Including NLRC4-GOF, XIAP Deficiency, or CDC42 Mutations
MAS825 tested as treatment for rare genetic inflammatory disorders caused by NLRC4, XIAP, or CDC42 mutations.
TrialA Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
Trial testing linvoseltamab alone or with carfilzomib versus standard treatments in patients with relapsed/refractory myeloma after 1-3 prior…
Education that still supports this area
SGLT2 Inhibitors: From Glycaemia to Heart Failure and Chronic Kidney Disease
recorded webinar focused on SGLT2 Inhibitors in diabetes and metabolic medicine. Use the recording with the slide outline…
WebinarJAK Inhibitors: Updated Safety Signals, Patient Selection and Post-ORAL Surveillance
Recorded webinar focused on JAK inhibitors in rheumatology and immune-mediated inflammatory disease. Reviews JAK-STAT signalling, patient selection, ORAL…
WebinarGLP-1 Agonists: Semaglutide, Tirzepatide and the Cardiovascular Revolution
recorded webinar focused on GLP-1 Agonists in diabetes and metabolic medicine. Use the recording with the slide outline…
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