Gastroenterology
Gastroenterology guidance, inflammatory bowel disease mechanisms, trial updates and education for clinicians following digestive disease evidence.
Latest Guidelines
Ex-situ machine perfusion devices to preserve deceased donor livers for transplantation
Consider ex-situ machine perfusion as an alternative to static cold storage for deceased donor livers, particularly for higher-risk grafts (extended criteria donors, prolonged cold ischaemia time)…
2022 ESPGHAN Guidelines on Coeliac Disease Diagnosis
This ESPGHAN guideline addresses 2022 ESPGHAN Guidelines on Coeliac Disease Diagnosis in Gastroenterology. Use it to review current recommendation wording, eligibility criteria, and implementation considerations in…
2023 EASL Clinical Practice Guidelines on Cirrhosis
This EASL guideline addresses 2023 EASL Clinical Practice Guidelines on Cirrhosis in Gastroenterology. Use it to review current recommendation wording, eligibility criteria, and implementation considerations in…
2023 EASL-EASD-EASO Clinical Practice Guidelines for MASLD
This EASL guideline addresses 2023 EASL-EASD-EASO Clinical Practice Guidelines for MASLD in Gastroenterology. Use it to review current recommendation wording, eligibility criteria, and implementation considerations in…
2022 EASL Clinical Practice Guidelines on Hepatitis C
This EASL guideline addresses 2022 EASL Clinical Practice Guidelines on Hepatitis C in Gastroenterology. Use it to review current recommendation wording, eligibility criteria, and implementation considerations…
Pancreatitis (NICE NG104)
Confirm acute pancreatitis diagnosis using serum lipase (or amylase if unavailable) with characteristic clinical features; perform baseline assessment including FBC, U&Es, LFTs, glucose, calcium, CRP and…
Trial Radar
Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis
A new drug called tilpisertib fosmecarbil tested against placebo in patients with moderate-to-severe ulcerative colitis to see if…
PHASE1Human Mass Balance Study of [14C] Ontunisertib in Healthy Volunteers
Study tracking how the body absorbs, processes and eliminates a single dose of ontunisertib using radioactive labelling in…
PHASE2A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).
What is being tested: A combination therapy using human albumin and enoxaparin (low-molecular-weight heparin) in hospitalised patients with…
TrialVision Baby : The Measurement of Vital Signs in Neonates by Lifelight® Software in Comparison to the Standard of Care
Vision Baby Study Summary Lifelight® software uses facial video to measure vital signs in newborns, compared against standard…
Clinical News
Mum’s perforated bowel ordeal after scan error
A patient developed life-threatening sepsis secondary to a perforated bowel that was missed on imaging during the postnatal…
10 Aug 2026England set to eliminate hepatitis C
Hepatitis C Elimination in England England is progressing toward hepatitis C elimination, positioning itself among the world's first…
03 Aug 2026Woman has pioneering womb surgery to fix ‘miracle’ baby with intestines outside its body
First in utero gastroschisis repair: Theo became the first British baby to undergo prenatal surgery to correct gastroschisis,…
19 Jul 2026I’ll lose my bowel because my pain was dismissed until my husband spoke up
Patient advocacy matters: Spousal involvement in clinical consultations increased credibility of symptom reporting and led to appropriate investigation…
Relevant Mechanisms
Alpha-4-Beta-7 Integrin — Gut-selective Lymphocyte Trafficking
Alpha-4-Beta-7 Integrin — Gut-selective Lymphocyte Trafficking is a clinically relevant Drug Science explainer. Lymphocyte trafficking to the intestinal mucosa is…
MechanismCFTR Modulation
CFTR Modulation is a clinically relevant Drug Science explainer. Cystic fibrosis (CF) is caused by mutations in the CFTR gene…
MechanismJAK-STAT Pathway
JAK-STAT Pathway is a clinically relevant Drug Science explainer. The Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway is…
MechanismS1P Receptor Modulation — MS/IBD
S1P Receptor Modulation — MS/IBD is a clinically relevant Drug Science explainer. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite generated…
MechanismThe IL-17/IL-23 Axis
The IL-17/IL-23 Axis is a clinically relevant Drug Science explainer. The IL-23/IL-17 axis is a central driver of immune-mediated inflammatory…
CPD, Podcasts & Webinars
No specialty-tagged education live yet
Gastroenterology podcasts, webinars and CPD modules will appear here as new education is published and tagged.
Useful starting points in Gastroenterology
Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis
A new drug called tilpisertib fosmecarbil tested against placebo in patients with moderate-to-severe ulcerative colitis to see if…
TrialHuman Mass Balance Study of [14C] Ontunisertib in Healthy Volunteers
Study tracking how the body absorbs, processes and eliminates a single dose of ontunisertib using radioactive labelling in…
TrialA Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).
What is being tested: A combination therapy using human albumin and enoxaparin (low-molecular-weight heparin) in hospitalised patients with…
Education that still supports this area
SGLT2 Inhibitors: From Glycaemia to Heart Failure and Chronic Kidney Disease
recorded webinar focused on SGLT2 Inhibitors in diabetes and metabolic medicine. Use the recording with the slide outline…
WebinarJAK Inhibitors: Updated Safety Signals, Patient Selection and Post-ORAL Surveillance
Recorded webinar focused on JAK inhibitors in rheumatology and immune-mediated inflammatory disease. Reviews JAK-STAT signalling, patient selection, ORAL…
WebinarGLP-1 Agonists: Semaglutide, Tirzepatide and the Cardiovascular Revolution
recorded webinar focused on GLP-1 Agonists in diabetes and metabolic medicine. Use the recording with the slide outline…
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