Mesalazine and idiopathic intracranial hypertension
Idiopathic intracranial hypertension (IIH) has been very rarely reported in patients treated with mesalazine. Following a recent review, warnings for IIH are being added to the product information…
Safety Radar
MHRA safety updates, clinically surfaced.
Drug safety updates, recalls and regulatory warnings from MHRA, organised for rapid clinical review and specialty follow-up.
54 safety updates
20 May 2026 latest update
MHRA source-linked
Latest Safety Update
Amiodarone: reminder of risks of treatment and need for patient monitoring and supervision
Amiodarone carries serious risks of pulmonary, hepatic, and thyroid toxicity requiring regular patient monitoring and supervision throughout treatment Healthcare professionals must ensure appropriate baseline investigations and regular follow-up assessments to detect potentially life-threatening adverse…
20 May 2026 · Read clinical summary
Drug Safety
MHRA sourceRecent MHRA Updates
Isotretinoin – updates to prescribing guidance and survey of services
The Commission on Human Medicines (CHM) has endorsed changes to isotretinoin prescribing guidance. In addition, CHM is seeking further information from dermatology services who prescribe isotretinoin to inform…
#MedSafetyWeek (3-9 November 2025): A call to action to improve patient safety
The annual #MedSafetyWeek campaign takes place from 3 to 9 November 2025. This year’s campaign theme is ‘we can all help make medicines safer.’ This update is best…
Paracetamol and pregnancy – reminder that taking paracetamol during pregnancy remains safe
Patients should be reminded and reassured that there is no evidence that taking paracetamol during pregnancy causes autism in children. Paracetamol is recommended as the first-choice pain reliever…
Abrysvo▼ (Pfizer RSV vaccine) and Arexvy▼ (GSK RSV vaccine): be alert to a small risk of Guillain-Barré syndrome following vaccination in older adults
There is a small increase in the risk of Guillain-Barré syndrome following vaccination with Abrysvo (Pfizer respiratory syncytial virus (RSV) vaccine) and Arexvy (GSK RSV vaccine) in adults…
Valproate (Belvo, Convulex, Depakote, Dyzantil, Epilim, Epilim Chrono or Chronosphere, Episenta, Epival, and Syonell▼): updated safety and educational materials to support patient discussion on reproductive risks
Updated safety and educational materials are now available to support the implementation of the regulatory measures announced in the November 2023 National Patient Safety Alert and the September…
Thiopurines and intrahepatic cholestasis of pregnancy
Thiopurines and intrahepatic cholestasis of pregnancy
Kaftrio▼ (Ivacaftor, tezacaftor, elexacaftor): risk of psychological side effects
Psychological side effects such as anxiety, low mood, sleep disturbance, poor concentration, and forgetfulness have been infrequently reported in people with cystic fibrosis treated with Kaftrio. Healthcare professionals…
Short-acting beta 2 agonists (SABA) (salbutamol and terbutaline): reminder of the risks from overuse in asthma and to be aware of changes in the SABA prescribing guidelines
Healthcare professionals and patients are reminded of the risk of severe asthma attacks and increased mortality associated with overuse of SABA with or without anti-inflammatory maintenance therapy in…
Fezolinetant▼(Veoza): risk of liver injury; new recommendations to minimise risk
Fezolinetant treatment is associated with a risk of drug induced liver injury. New recommendations have been introduced to minimise this risk. Liver function should be monitored before and…
Prolonged-release opioids: Removal of indication for relief of post-operative pain
Prolonged-release opioids: Removal of indication for relief of post-operative pa...
Letters and medicine recalls sent to healthcare professionals in January 2025
A summary of recent letters and notifications sent to healthcare professionals about medicines and medical devices. This update is best treated as a linked clinical news item for…