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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

1963 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

1963 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

active not recruiting Phase III
A Study of Acalabrutinib vs Investigator’s Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in R/R CLL
Acalabrutinib compared to chemotherapy plus antibody therapy for previously treated blood cancer patients.
24 Jul 2026 NCT02970318
active not recruiting Phase I
A Phase 1b Study to Investigate Safety and Tolerability of ARGX-119 in Adult Participants With DOK7-Congenital Myasthenic Syndromes (CMS)
Early-stage trial testing safety of ARGX-119 infusions in adults with DOK7 muscle weakness syndrome.
24 Jul 2026 NCT06436742
● Recruiting Phase III Rheumatology
Apremilast Pediatric Study in Children With Active Juvenile Psoriatic Arthritis
Apremilast was tested against placebo in children aged 5-17 with juvenile psoriatic arthritis to assess its effectiveness.
24 Jul 2026 NCT04804553
active not recruiting Phase III
Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)
Long-term safety study of secukinumab (an IL-17 inhibitor) in patients with polymyalgia rheumatica to assess tolerability and adverse effects.
24 Jul 2026 NCT06331312
● Recruiting Phase III Respiratory / COPD / Asthma
A Study to Find Out How Nerandomilast is Tolerated, Handled by the Body, and if it Helps Children and Adolescents With Interstitial Lung Disease (FIBRONEER-chILD)
Trial testing nerandomilast tolerance and effectiveness in children aged 2-17 with interstitial lung disease over 2.5-5 years.
24 Jul 2026 NCT07366034
● Recruiting Respiratory / COPD / Asthma
A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems
What is being tested: A study evaluating the pathophysiology of inherited alpha-1 antitrypsin deficiency (AATD), specifically how abnormal Z-AAT protein accumulates in liver cells…
24 Jul 2026 NCT06512454
● Recruiting Phase III Cardiology / Cardiovascular
Apremilast Pediatric Study in Children With Active Oral Ulcers Associated With Behçet’s Disease
Intervention tested: Apremilast (a phosphodiesterase-4 inhibitor) versus placebo for treating oral ulcers in children with Behçet's disease, addressing a significant unmet need in pediatric…
24 Jul 2026 NCT04528082
● Recruiting Phase III Cardiology / Cardiovascular
Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
Treatment tested: Inclisiran, a PCSK9 inhibitor administered via subcutaneous injection, being evaluated for its ability to lower LDL cholesterol in paediatric patients with homozygous…
24 Jul 2026 NCT06597006
● Recruiting Phase III Oncology
Vorasidenib Maintenance for IDH Mutant Astrocytoma
What is being tested: Vorasidenib (an IDH inhibitor) as maintenance therapy post-chemoradiotherapy versus placebo in IDH-mutant astrocytoma, with progression-free survival as the primary endpoint.…
24 Jul 2026 NCT06809322
● Recruiting Oncology
Evaluation of the Ileo-anal Pouch in FAP (ENDOPOL)
What is being tested: This RCT compares dye-based chromoendoscopy versus virtual chromoendoscopy (NBI/BLI technology) for detecting adenomas during surveillance pouchoscopy in FAP patients with…
24 Jul 2026 NCT07726771
● Recruiting Phase II Oncology
A Study To Assess the Safety, Tolerability, and Efficacy of Imzokitug in Combination With Pumitamig and Platinum-Doublet Chemotherapy (PDCT) Versus Pumitamig and PDCT as First-line Treatment for Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
What is being tested: The trial evaluates imzokitug added to pumitamig plus platinum-doublet chemotherapy versus pumitamig plus chemotherapy alone as first-line treatment for locally…
24 Jul 2026 NCT07680764
active not recruiting Phase I / Phase II Oncology
First-in-Human Study of ICT01 in Patients With Advanced Cancer
New antibody drug (ICT01) tested alone and with pembrolizumab in advanced cancer patients to find safe doses and effectiveness.
23 Jul 2026 NCT04243499
active not recruiting Phase III Oncology
A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer
Trial comparing new cancer-targeting drug sigvotatug vedotin versus standard docetaxel chemotherapy in previously treated advanced lung cancer patients.
23 Jul 2026 NCT06012435
active not recruiting Phase II / Phase III
A Study to Examine the Efficacy and Safety of Zanubrutinib Given to Adults With Primary Membranous Nephropathy
Zanubrutinib reduced protein in urine in primary membranous nephropathy patients and was compared against standard tacrolimus treatment.
23 Jul 2026 NCT05707377
active not recruiting Phase III Oncology
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
MRTX849 plus cetuximab compared to chemotherapy for advanced bowel cancer with specific KRAS mutation.
23 Jul 2026 NCT04793958
● Recruiting Phase II Rheumatology
A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
Phase 2 trial testing two immunosuppressive drugs in patients with treatment-resistant lupus and rheumatoid arthritis.
23 Jul 2026 NCT06570798
active not recruiting Phase III Oncology
A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy
Trial testing whether adding tiragolumab to atezolizumab improves outcomes in advanced oesophageal cancer after chemoradiotherapy.
23 Jul 2026 NCT04543617
● Recruiting Phase I Oncology
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
What is being tested: MOMA-313, an oral therapeutic agent, is undergoing Phase 1 evaluation for safety, tolerability, pharmacokinetics, and preliminary anti-tumour activity in patients…
23 Jul 2026 NCT06545942
● Recruiting Phase III Neurology
An Evaluation of Treatments for Sustained Clinical Response (18 Months) in Symptomatic Alzheimer’s Disease
What is being tested: A Phase 3 trial evaluating multiple treatment approaches for sustained clinical response over 18 months in symptomatic Alzheimer's disease, using…
23 Jul 2026 NCT07724132
● Recruiting Cardiology / Cardiovascular
Neuropsychiatric Outcomes and Disrupted Sleep Following Acquired Brain Injury
What is being tested: The relationship between sleep quality and neuropsychiatric outcomes (mental health problems) in patients following acquired brain injury from stroke or…
23 Jul 2026 NCT07215195
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
What is being tested: The combination of finerenone (a non-steroidal mineralocorticoid receptor antagonist) plus empagliflozin (an SGLT2 inhibitor) versus standard care in hospitalised heart…
23 Jul 2026 NCT06024746
● Recruiting Cardiology / Cardiovascular
Placental Biology in Health and Disease
What is being tested: This trial investigates placental biological mechanisms underlying pre-eclampsia (hypertension with organ damage) and gestational diabetes mellitus (abnormal glucose metabolism in…
23 Jul 2026 NCT07470320
● Recruiting Oncology
Is the Use of a Steam Mask an Effective Treatment for Paediatric Chalazion in Comparison to Traditional Warm Compresses?
What is being tested: This trial compares the effectiveness of a steam mask versus traditional warm compresses as treatments for chalazion (a common eyelid…
23 Jul 2026 NCT07721779
● Recruiting Phase I Oncology
A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
What is being tested: INCA33890, a novel investigational agent, is undergoing a dose-escalation safety and tolerability study in patients with advanced or metastatic solid…
23 Jul 2026 NCT05836324
active not recruiting Phase II Dermatology
A Study Evaluating APG777 in Atopic Dermatitis
Trial testing a new drug (APG777) to treat moderate-to-severe eczema, comparing different doses against placebo over 106 weeks.
22 Jul 2026 NCT06395948
active not recruiting Phase II Oncology
A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer
Trial testing two new drugs combined with standard chemotherapy for advanced biliary tract cancer to assess effectiveness and safety.
22 Jul 2026 NCT02711553
● Recruiting Phase I / Phase II Oncology
Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
Trial testing ubamatamab alone or combined with cemiplimab in recurrent ovarian and other MUC16-positive cancers, assessing safety, dosing, and effectiveness.
22 Jul 2026 NCT03564340
● Recruiting Phase III Oncology
EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma
Trial testing whether adding immunotherapy (pembrolizumab) to standard glioblastoma treatment improves survival compared to standard treatment alone.
22 Jul 2026 NCT06556563
● Recruiting Phase III Gastroenterology
A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD
Trial testing a surgically implanted eye device that delivers ranibizumab every 36 weeks for age-related macular degeneration.
22 Jul 2026 NCT06847542
active not recruiting Phase III Oncology
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
Pembrolizumab added to chemotherapy versus chemotherapy alone for advanced hormone receptor-positive breast cancer, with PFS as primary endpoint in PD-L1 positive patients.
22 Jul 2026 NCT04895358
active not recruiting Cardiology / Cardiovascular
STOP Persistent AF PAS
STOP Persistent AF Post Approval Study A worldwide study tracking real-world outcomes in patients receiving treatment for persistent atrial fibrillation outside controlled trial settings.
22 Jul 2026 NCT05005949
● Recruiting Phase III Diabetes / Metabolic
Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes
What is being tested: Ribupatide (KAI-9531), a novel once-weekly subcutaneous injection, is being evaluated for weight reduction in people with obesity without diabetes, compared…
22 Jul 2026 NCT07284979
● Recruiting Phase I Oncology
A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer
Drug being tested: PF-08052667 is a novel investigational medicine being evaluated as monotherapy or in combination with BCG (standard intravesical immunotherapy) and/or sasanlimab (an…
22 Jul 2026 NCT07206225
● Recruiting Phase III Oncology
DAREON®-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer (epNEC) to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy
What is being tested: Obrixtamig (a DLL3-targeting therapy) combined with carboplatin and etoposide chemotherapy versus standard chemotherapy alone in patients with advanced extrapulmonary neuroendocrine…
22 Jul 2026 NCT07544654
● Recruiting Phase I Oncology
A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)
What is being tested: Different dose combinations of BI 1703880 (an experimental medicine) with ezabenlimab (an existing immunotherapy) to determine tolerability and the maximum…
22 Jul 2026 NCT05471856
● Recruiting Phase II Oncology
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
What is being tested: Disitamab vedotin (a HER2-targeted antibody-drug conjugate) as monotherapy or in combination with pembrolizumab (PD-L1 inhibitor) for HER2-expressing urothelial cancer, evaluating…
22 Jul 2026 NCT04879329
● Recruiting Phase III
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of GM1 Gangliosidosis or GM2 Gangliosidosis
Oral nizubaglustat tested against placebo over 18 months in children with late-infantile or juvenile GM1/GM2 gangliosidosis.
21 Jul 2026 NCT07082543
● Recruiting Phase II
A 16-week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream 20 mg/g in Adult Participants With Mild to Severe Palmoplantar Pustulosis
Delgocitinib cream twice daily reduced symptoms of palmoplantar pustulosis more effectively than placebo cream over 16 weeks.
21 Jul 2026 NCT07013201
● Recruiting
PMCF (Post-Market Clinical Follow-up) Study on The Tether™ in UK (United Kingdom)
A study monitoring safety and effectiveness of The Tether™ device in UK patients undergoing surgery for childhood scoliosis.
21 Jul 2026 NCT05830825
active not recruiting Phase III Oncology
A Clinical Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) to Treat Newly-diagnosed Metastatic Non-small Cell Lung Cancer (MK-3475A-F84)
Trial comparing subcutaneous versus intravenous pembrolizumab delivery for newly-diagnosed metastatic non-small cell lung cancer.
21 Jul 2026 NCT06698042
● Recruiting Phase II
A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis
Trial testing efgartigimod injection versus placebo for systemic sclerosis over 48 weeks to assess safety and effectiveness.
21 Jul 2026 NCT06655155
active not recruiting Phase II Oncology
A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma
Trial testing new drug ABBV-400 combined with chemotherapy and immunotherapy for advanced stomach and gullet cancers.
21 Jul 2026 NCT06628310
● Recruiting Phase III
A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP
Trial comparing new drug empasiprubart against standard IVIg treatment for CIDP over 24 weeks, then all patients receive empasiprubart for 24 months.
21 Jul 2026 NCT06920004
active not recruiting Phase III Rheumatology
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
A drug called obinutuzumab added to standard lupus kidney treatment improved kidney function and was safe compared to placebo.
21 Jul 2026 NCT04221477
● Recruiting Rheumatology
Metagenomics for Ocular Inflammation
What is being tested: Metagenomic sequencing is being evaluated as a diagnostic tool to identify infectious agents in patients with ocular inflammation when standard…
21 Jul 2026 NCT06974162
● Recruiting Phase III Respiratory / COPD / Asthma
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
Treatment being tested: Tozorakimab (a monoclonal antibody) administered as an add-on to standard care in hospitalised patients with viral lung infection requiring supplemental oxygen,…
21 Jul 2026 NCT05624450
● Recruiting Phase I Oncology
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations
What is being tested: The safety and efficacy of T cell engaging bi/tri-specific antibodies administered intravenously or subcutaneously, either as monotherapy or in combination…
21 Jul 2026 NCT06892522
● Recruiting Cardiology / Cardiovascular
The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study
Testing early surgical aortic valve replacement in asymptomatic severe aortic stenosis patients versus the standard watchful waiting approach to determine whether proactive intervention improves…
21 Jul 2026 NCT04204915
● Recruiting Phase I Oncology
First Time in Human (FTIH) Study to Investigate the Safety and Preliminary Activity of GSK5533524 Alone or in Combination in Adult Participants With Advanced Solid Tumors
Drug Being Tested: GSK5533524, a novel investigational agent, is being evaluated in a first-in-human study as monotherapy and in combination regimens to establish safety,…
21 Jul 2026 NCT07438782
● Recruiting Oncology
DRAGON Registry – International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
What is being tested: Combined portal and hepatic vein embolization (PVE/HVE) as a preoperative strategy to increase future liver remnant volume before surgical resection…
21 Jul 2026 NCT07717437