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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

2231 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

2231 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

● Recruiting Phase III Cardiology / Cardiovascular
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
What is being tested: Zenagamtide (a novel GLP-1 receptor agonist) versus insulin glargine for glycaemic control and weight reduction in type 2 diabetes patients…
01 Sep 2026 NCT07797335
● Recruiting Phase III Oncology
A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy
What is being tested: Inavolisib combined with fulvestrant versus alpelisib combined with fulvestrant in HR-positive, HER2-negative, PIK3CA-mutated breast cancer patients who have progressed after…
01 Sep 2026 NCT05646862
● Recruiting Phase III Oncology
Accelerated v’s Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours
What is being tested: Accelerated dosing schedule of BEP chemotherapy (bleomycin, etoposide, cisplatin) compared to standard dosing in men with intermediate and poor-risk metastatic…
01 Sep 2026 NCT02582697
active not recruiting Cardiology / Cardiovascular
Point of Care NT-proBNP Testing for Suspected New Heart Failure Acute Care
Point-of-care NT-proBNP testing speeds heart failure diagnosis in acute settings, potentially improving patient outcomes and treatment times.
31 Aug 2026 NCT07793968
active not recruiting Phase II Gastroenterology
A Phase 2a/b Study of the Efficacy and Safety of Subcutaneous Amlitelimab in Adults With Nonresponsive Celiac Disease
A trial testing whether amlitelimab injection reduces intestinal damage in adults with celiac disease unresponsive to gluten-free diet alone.
31 Aug 2026 NCT06557772
active not recruiting Phase III Oncology
An Efficacy and Safety Study of Apalutamide (JNJ-56021927) in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Participants With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC)
Adding apalutamide to standard hormone therapy improves progression-free survival in men with advanced prostate cancer.
31 Aug 2026 NCT02257736
active not recruiting Phase III Oncology
A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions
Adding amivantamab to standard chemotherapy improves progression-free survival in advanced lung cancer with EGFR exon 20 mutations.
31 Aug 2026 NCT04538664
active not recruiting Phase III Diabetes / Metabolic
A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight
CagriSema, a new weight-loss injection, is being tested against dummy medicine and two alternatives in a 1.5-year trial, followed by observation after treatment stops.
31 Aug 2026 NCT05567796
● Recruiting Gastroenterology
Long-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)
What is being tested: Long-term safety profile and durability of therapeutic response in participants who received investigational products (IP) across iECURE parent protocols, alongside…
31 Aug 2026 NCT06805695
● Recruiting Phase I Oncology
A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors
What is being tested: CTIM-76, a CLDN6-directed T cell-engaging bispecific antibody, is being evaluated in a Phase 1a/1b dose escalation and expansion study to…
31 Aug 2026 NCT06515613
active not recruiting Phase II Gastroenterology
A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis
Combining two biologic drugs (guselkumab and golimumab) tested for treating ulcerative colitis in patients who haven't responded to other treatments.
28 Aug 2026 NCT05242484
active not recruiting
Survivorship of Attune Primary Total Knee Prosthesis
Study tracking how long Attune knee replacements last in patients with osteoarthritis over 15 years.
28 Aug 2026 NCT01754363
● Recruiting Phase III Rheumatology
A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis
New drug icotrokinra tested against placebo for psoriatic arthritis in patients with and without previous biologic treatment.
28 Aug 2026 NCT06807424
active not recruiting Phase II Gastroenterology
A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn’s Disease
Testing whether combining two existing Crohn's drugs works better than either drug alone at 48 weeks.
28 Aug 2026 NCT05242471
active not recruiting Phase III Oncology
Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)
New cancer drug sacituzumab tirumotecan tested against chemotherapy in previously treated endometrial cancer patients to assess survival benefits.
28 Aug 2026 NCT06132958
active not recruiting Rheumatology
A Study of Guselkumab and Interleukin-17 (IL-17) Inhibitor Therapies in Participants With Psoriatic Arthritis in Routine Clinical Practice
This study compared how long patients stayed on guselkumab or IL-17 inhibitor treatments for psoriatic arthritis in routine clinical practice.
28 Aug 2026 NCT05049798
● Recruiting Oncology
Secondary Care Colorectal Cancer Pathway Review
What is being tested: A secondary care colorectal cancer pathway review examining systems and processes for detecting, diagnosing, and managing bowel cancer in hospital…
28 Aug 2026 NCT07430527
● Recruiting Oncology
Optimising Colorectal Cancer Patient Pathways
What is being tested: This trial optimises colorectal cancer patient pathways to improve early detection and survival outcomes through enhanced screening and diagnostic processes…
28 Aug 2026 NCT07430540
● Recruiting Phase III Rheumatology
A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis
What is being tested: JNJ-78934804, a novel therapeutic agent, is being evaluated for efficacy and safety in treating moderately to severely active ulcerative colitis,…
28 Aug 2026 NCT07577856
● Recruiting Phase III Oncology
MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)
What is being tested: Adjuvant calderasib (a KRAS G12C inhibitor) combined with pembrolizumab immunotherapy versus pembrolizumab alone in completely resected early-stage NSCLC with KRAS…
28 Aug 2026 NCT07431827
● Recruiting Cardiology / Cardiovascular
Longitudinal Study for Eosinophilic Granulomatosis With Polyangiitis
What is being tested: A longitudinal observational study collecting long-term clinical data on eosinophilic granulomatosis with polyangiitis (EGPA) to better understand disease progression, treatment…
28 Aug 2026 NCT00315380
● Recruiting Phase I Oncology
A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer
What is being tested: Amivantamab (an EGFR/MET bispecific antibody) is being evaluated as monotherapy and in combination with pembrolizumab, paclitaxel, or pembrolizumab plus carboplatin…
28 Aug 2026 NCT06385080
● Recruiting Phase II Oncology
Testing Ivonescimab Versus FOLFOX in Advanced Biliary Tract Cancer Patients
What is being tested: Ivonescimab (a PD-L1/CTLA-4 bispecific antibody) is being compared against standard FOLFOX chemotherapy in patients with advanced biliary tract cancer who…
28 Aug 2026 NCT06529718
● Recruiting Phase III Oncology
A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer
What is being tested: TAR-210 (a novel intravesical therapeutic) is being compared against standard single-agent intravesical chemotherapy to evaluate which approach better prevents recurrence…
28 Aug 2026 NCT06319820
active not recruiting Phase II / Phase III Dermatology
Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials
Long-term safety and efficacy study of amlitelimab for moderate-to-severe atopic dermatitis, including drug withdrawal to assess treatment durability.
27 Aug 2026 NCT05492578
active not recruiting Phase III
A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period
Mitapivat reduces transfusion need in children with pyruvate kinase deficiency compared to placebo.
27 Aug 2026 NCT05144256
active not recruiting Phase III Oncology
HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy
HERTHENA-Lung02 Summary Patritumab deruxtecan compared to chemotherapy for advanced lung cancer with EGFR mutations that stopped responding to targeted drugs.
27 Aug 2026 NCT05338970
● Recruiting Phase III
A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis
Bimekizumab was tested against placebo in patients with palmoplantar pustulosis to assess its effectiveness and safety.
27 Aug 2026 NCT07219420
● Recruiting Phase I Respiratory / COPD / Asthma
A Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Two GSK3862995B Formulations in Healthy Participants
What is being tested: Two different formulations of GSK3862995B, an investigational medicine, are being compared to evaluate their pharmacokinetics (absorption, distribution, metabolism, and elimination),…
27 Aug 2026 NCT07789899
● Recruiting Phase III Oncology
Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
What is being tested: Daraxonrasib, a novel RAS(ON) inhibitor, evaluated both as monotherapy and in combination with gemcitabine/nab-paclitaxel (GnP) chemotherapy versus standard chemotherapy alone…
27 Aug 2026 NCT07491445
● Recruiting Oncology
A Multimodal Integrated Intervention for Kidney Cachexia
Combined exercise, dietary advice, and anti-inflammatory supplements may help prevent severe muscle wasting in haemodialysis patients.
26 Aug 2026 NCT07107087
active not recruiting Phase II Diabetes / Metabolic
HM15136 (Efpegerglucagon) Treatment for 8 Weeks in Subjects Aged ≥2 Years With Congenital Hyperinsulinism (CHI)
Eight-week study testing weekly injections of HM15136 as add-on treatment for children with congenital hyperinsulinism who remain hypoglycaemic.
26 Aug 2026 NCT04732416
● Recruiting
An Observational Study to Collect Data on How Aflibercept (Eylea) Given Using a Paediatric Dosing Device is Used in Preterm Babies With Retinopathy of Prematurity in the United Kingdom (UK)
UK study collecting data on how many premature babies receive eye injections of aflibercept for retinopathy using a special dosing device.
26 Aug 2026 NCT06315556
active not recruiting Phase III Neurology
A Study of Donanemab (LY3002813) in Participants With Early Alzheimer’s Disease (TRAILBLAZER-ALZ 2)
Donanemab slows cognitive decline in early Alzheimer's disease; follow-up study monitors long-term safety and effectiveness.
26 Aug 2026 NCT04437511
● Recruiting
Satiety, Microbiome, Appetite Regulation, and Tracking Energy Across Targeted Snacks: Chronic Study
Seven-week remote study comparing two snack bars to assess effects on daily hunger, gut health, and digestive symptoms in healthy adults.
26 Aug 2026 NCT07782593
active not recruiting Phase I Gastroenterology
A First-time in Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK4528287 in Healthy Participants
A new experimental drug (GSK4528287) for inflammatory bowel disease is being tested in healthy volunteers for the first time to check safety and how…
26 Aug 2026 NCT06681181
active not recruiting Phase II
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)
Volixibat tested for reducing itching in patients with PSC and potentially slowing disease progression.
26 Aug 2026 NCT04663308
active not recruiting Phase I / Phase II Oncology
Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer
Trial testing whether combining AZD5305 with hormone therapies is safe and effective for advanced prostate cancer.
26 Aug 2026 NCT05367440
● Recruiting Phase I Rheumatology
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
Early-stage trial testing a new injection drug's safety, tolerability, and how the body processes it in patients with rheumatoid arthritis or lupus.
26 Aug 2026 NCT07201558
● Recruiting Oncology
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
What is being tested: Advanced cardiac imaging techniques to detect and evaluate myocardial fibrosis progression in patients with cardiomyopathies and heart muscle diseases, focusing…
26 Aug 2026 NCT06409585
● Recruiting Cardiology / Cardiovascular
Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)
What is being tested: A pragmatic randomised controlled trial comparing the effects of high versus standard blood phosphate targets in patients with end-stage kidney…
26 Aug 2026 NCT03573089
● Recruiting Phase I Oncology
Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell Carcinoma
What is being tested: VB10.16 (therapeutic DNA vaccine) combined with pembrolizumab (PD-1 inhibitor) in patients with unresectable recurrent or metastatic HPV16-positive oropharyngeal head and…
26 Aug 2026 NCT06016920
● Recruiting Oncology
The PROSECCA Study, Answering New Questions in Prostate Cancer
What is being tested: The PROSECCA study evaluates radiotherapy techniques and strategies for prostate cancer treatment, specifically investigating methods to minimise damage to healthy…
26 Aug 2026 NCT06714630
active not recruiting Phase II Oncology
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
Entrectinib treats solid cancers with specific genetic fusions (NTRK, ROS1, ALK), grouped by cancer type and mutation.
25 Aug 2026 NCT02568267
active not recruiting Phase I Oncology
Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors
Phase 1 trial testing dostarlimab, a new PD-1 immunotherapy antibody, for safety and effectiveness in advanced cancer patients.
25 Aug 2026 NCT02715284
active not recruiting Phase III
A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa
Long-term safety and effectiveness study of povorcitinib for moderate to severe hidradenitis suppurativa in patients completing earlier trials.
25 Aug 2026 NCT06212999
active not recruiting Rheumatology
Anatomical Shoulder Domelock System Study
This study confirms a new shoulder replacement system is safe and works well by checking patient scores, X-rays and complications.
25 Aug 2026 NCT03312465
active not recruiting Phase II
Study to Evaluate Tulisokibart for Hidradenitis Suppurativa (MK-7240-012)
Tulisokibart tested against placebo in moderate-to-severe skin infection; primary outcome was 50% symptom improvement at 16 weeks.
25 Aug 2026 NCT06956235
● Recruiting Respiratory / COPD / Asthma
The Role of METhanogens in the PROgression Of Parkinson’s Disease and Related Neurological Conditions
What is being tested: The study investigates whether methane-producing gut bacteria (methanogens) contribute to Parkinson's disease progression and related neurological conditions, examining the mechanistic…
25 Aug 2026 NCT07786116
● Recruiting Cardiology / Cardiovascular
Feasibility of a Physiotherapy Programme, With Integrated telerehabIlitation to Increase Rehabilitation Time and Improve Motor Function
What is being tested: A physiotherapy programme incorporating telerehabiliation technology designed to increase total rehabilitation time and improve motor function recovery in stroke patients.…
25 Aug 2026 NCT06871878