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Trial Radar

1003 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

1003 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

● Recruiting Phase III Oncology
AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL
The purpose of this study is to measure the efficacy and safety of R-mini-CHOP × 2 followed by AZD0486 compared with R-mini-CHOP × 6…
21 Apr 2026 NCT07215585
● Recruiting Oncology
Bronchoscopic Microwave Ablation of Lung Tissue in Surgical Candidates – UK
This study involves the use of a medical device, the Creo Medical MicroBlate Flex instrument, to heat and destroy lung tumour cells using microwave…
21 Apr 2026 NCT06869122
● Recruiting Phase I Oncology
AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies.
This study is designed to evaluate the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy following oral administration of AZD3470 as a monotherapy, and in…
21 Apr 2026 NCT06137144
● Recruiting Phase III Oncology
SUPRAME-ACTengine® IMA203 vs. Investigator’s Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
This clinical trial is a prospective, multicenter, open-label, randomized, actively controlled, parallel-group Phase 3 clinical trial to evaluate the efficacy, safety and tolerability of…
21 Apr 2026 NCT06743126
● Recruiting Phase II Rheumatology
A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)
Tulisokibart (MK-7240) is being tested to see if it can improve symptoms of radiographic axial spondyloarthritis better than placebo.
20 Apr 2026 NCT07133633
active not recruiting Phase III Cardiology / Cardiovascular
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) – ACCLAIM-Lp(a)
Lepodisiran injection reduces heart attacks and strokes in patients with high lipoprotein(a) levels and existing heart disease.
20 Apr 2026 NCT06292013
active not recruiting Phase II
Extended Access of Momelotinib in Adults With Myelofibrosis
Momelotinib Extended Access Trial Summary This study provides ongoing access to momelotinib for myelofibrosis patients and monitors long-term safety and survival.
20 Apr 2026 NCT03441113
active not recruiting
The Use of DXA in Scoliosis
Pilot study testing whether lying-down DXA scans can accurately measure scoliosis curves and help with brace design compared to standard standing X-rays.
20 Apr 2026 NCT06512038
active not recruiting
Single Palatal Temporary Anchorage Device for Anterior Open Bite
A single palatal screw was as effective as two cheek screws for closing open bites using fixed braces.
20 Apr 2026 NCT04419805
active not recruiting Phase I / Phase II
Safety and Tolerability of BION-1301 in Healthy Volunteers and Adults With IgA Nephropathy (IgAN)
BION-1301 was tested for safety and tolerability in healthy people and IgA kidney disease patients.
20 Apr 2026 NCT03945318
● Recruiting Phase I Oncology
A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and preliminary activity of RO7656594 in participants with advanced or metastatic prostate…
20 Apr 2026 NCT05800665
● Recruiting Phase III Oncology
A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).
Pfizer MEVPRO-1 (C2321014) is a randomized, open-label, multi-center clinical trial evaluating whether combining the study medicine (PF-06821497) with enzalutamide is safe and effective compared…
20 Apr 2026 NCT06551324
● Recruiting Phase III Oncology
Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)
A Phase Ib/III Open-label, Randomised Study of Capivasertib plus CDK4/6 Inhibitors and Fulvestrant versus CDK4/6 Inhibitors and Fulvestrant in Hormone Receptor-Positive and Human Epidermal…
20 Apr 2026 NCT04862663
● Recruiting Phase II Oncology
A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer
The main purpose of this study is to evaluate the safety and efficacy of novel study interventions and combinations in participants with Colorectal Cancer…
20 Apr 2026 NCT06792695
● Recruiting Phase II Rheumatology
Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
The overall purpose of this two-part study is to evaluate the efficacy, safety and tolerability of iptacopan (LNP023) in addition to standard of care…
20 Apr 2026 NCT05268289
● Recruiting Phase III Respiratory / COPD / Asthma
Outpatient Treatment With Anti-Coronavirus Immunoglobulin
The primary objective of the Outpatient Treatment with Anti-Coronavirus Immunoglobulin (OTAC) (INSIGHT 012) trial is to compare the safety and efficacy of a single…
20 Apr 2026 NCT04910269
● Recruiting Respiratory / COPD / Asthma
GEneRating Mucosal Immunity After INfluenzA Infection and Vaccination in Lung and Lymphoid TissuE
This experimental medicine study aims to compare immune responses in healthy adult volunteers aged 18-55 years against influenza vaccination and infection in the upper…
20 Apr 2026 NCT06620185
● Recruiting Phase III Oncology
DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemotherapy
This study is open to adults with advanced small cell lung cancer (SCLC). The purpose of this study is to find out if a…
20 Apr 2026 NCT07472517
● Recruiting Phase I Oncology
A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and activity of single-agent divarasib or combined with other anti-cancer therapies in…
20 Apr 2026 NCT05789082
● Recruiting Phase I Oncology
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
This study will test the safety of a drug called PF-08046054/SGN-PDL1V alone and with pembrolizumab in participants with solid tumors. It will also study…
20 Apr 2026 NCT05208762
● Recruiting Cardiology / Cardiovascular
Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery
Coronary artery bypass graft (CABG) surgery is the commonest type of heart operation performed. During this, arteries or veins (termed 'grafts') are used to…
20 Apr 2026 NCT06800430
● Recruiting Phase III Oncology
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
The primary objectives are to compare progression-free survival (PFS) and overall survival (OS) in participants who receive sotorasib with platinum doublet chemotherapy versus participants…
20 Apr 2026 NCT05920356
● Recruiting Phase I Oncology
Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer
The study will be conducted in 4 parts and will commence with dose escalation of VIR-5500 as a monotherapy (Part 1), followed by combination…
20 Apr 2026 NCT05997615
● Recruiting Phase I Oncology
A Phase I Study of BAY3498264 Given Together With Sotorasib in Participants Who Have Advanced Solid Cancers With Specific Genetic Changes Called KRASG12C Mutation
Researchers are looking for a better way to treat people who have advanced solid cancers with a KRASG12C mutation. Sotorasib is a drug that…
20 Apr 2026 NCT06659341
● Recruiting Phase I Oncology
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma
This study will evaluate the safety, efficacy, and pharmacokinetics of mosunetuzumab or glofitamab in combination with CELMoDs (CC-220 and/or CC-99282) in participants with B-cell…
20 Apr 2026 NCT05169515
● Recruiting Phase II Women's Health
A Phase 2 Trial to Investigate Efficacy and Safety of Vipoglanstat in Women With Endometriosis
A study testing whether vipoglanstat reduces pelvic pain in women with endometriosis, beyond pain linked to periods.
17 Apr 2026 NCT07260669
active not recruiting Phase II
A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathy
Trial testing whether BI 764524 injection helps moderate-to-severe diabetic retinopathy, comparing different dosing schedules against sham control.
17 Apr 2026 NCT06321302
active not recruiting Phase III Diabetes / Metabolic
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
Weekly semaglutide injections tested against placebo over 5 years to see if it helps fatty liver disease.
17 Apr 2026 NCT04822181
active not recruiting Phase I Oncology
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
A study testing a new oral drug (MOMA-313) in patients with advanced cancers, assessing safety, dosage, and effectiveness alone or combined.
17 Apr 2026 NCT06545942
● Recruiting Phase I
A Study to Evaluate ALN-4285 in Adult Healthy Volunteers
ALN-4285 safety, tolerability, and how the body processes single doses tested in healthy adults.
17 Apr 2026 NCT07295717
active not recruiting Neurology
Psilocybin in Functional Neurological Disorder
Single psilocybin dose with therapy may alter brain network activity in functional neurological disorder patients.
17 Apr 2026 NCT05723276
● Recruiting Phase I / Phase II
A Study of Pirtobrutinib in Participants With Immune Thrombocytopenia
Phase 1/2 trial testing oral pirtobrutinib for immune thrombocytopenia, evaluating safety, tolerability, and effectiveness at different doses.
17 Apr 2026 NCT06721013
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
What is being tested: Finerenone (a non-steroidal mineralocorticoid receptor antagonist) efficacy, safety, and pharmacokinetics in children with heart failure and left ventricular systolic dysfunction,…
17 Apr 2026 NCT07188805
● Recruiting Phase I Oncology
A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment BNT327 and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer
Treatment Being Tested: BNT314 (immunotherapy) combined with BNT327 (immune checkpoint inhibitor) and chemotherapy in a randomised, multi-site design to evaluate efficacy and safety in…
17 Apr 2026 NCT07079631
● Recruiting Phase II Oncology
NEOadjuvant PembRolizumab In Stratified Medicine – ColoRectal Cancer
What is being tested: Neoadjuvant pembrolizumab (an anti-PD-1 immunotherapy) combined with standard chemotherapy and/or radiotherapy in stratified cohorts of early-stage colorectal cancer patients, assessed…
17 Apr 2026 NCT05197322
● Recruiting Phase I Oncology
A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer
Treatment being tested: BNT323 combined with BNT327 (both investigational agents) to determine optimal dosing, safety profile, and clinical efficacy in advanced breast cancer across…
17 Apr 2026 NCT06827236
● Recruiting Phase II Neurology
Safety and Efficacy of EXV-802 and EXV-801 in the Treatment of Agitation in Alzheimer’s Disease Dementia
What is being tested: EXV-802 and EXV-801 are novel investigational agents being evaluated for their safety and efficacy in treating agitation symptoms in patients…
17 Apr 2026 NCT07284472
● Recruiting Phase II Oncology
Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer
What is being tested: Novel immunomodulators administered as monotherapy and in combination with anticancer agents to evaluate their efficacy, safety, and tolerability in advanced…
17 Apr 2026 NCT05775159
● Recruiting Phase III Cardiology / Cardiovascular
A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria
Treatment being tested: Finerenone (a non-steroidal mineralocorticoid receptor antagonist) in combination with ACE inhibitors or angiotensin receptor blockers in children with chronic kidney disease…
17 Apr 2026 NCT05196035
● Recruiting Phase IV Diabetes / Metabolic
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
What is being tested: Tirzepatide (a dual GIP/GLP-1 receptor agonist) versus standard obesity care in a real-world UK setting, measuring weight loss and type…
17 Apr 2026 NCT07247084
● Recruiting Phase II Diabetes / Metabolic
A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
What is being tested: LY3457263, a novel investigational agent, is being evaluated as an add-on therapy to semaglutide or tirzepatide in patients whose blood…
17 Apr 2026 NCT06897475
● Recruiting Diabetes / Metabolic
Determining the Effect of Food Ordering on Blood Glucose In Gestational Diabetes Mellitus (DEFI-GDM)
What is being tested: The trial investigates whether the order of macronutrient consumption (carbohydrates, proteins, fats) during meals affects postprandial blood glucose levels in…
17 Apr 2026 NCT06896799
● Recruiting Diabetes / Metabolic
Real-World Study of Patients With Type 1 Diabetes Treated With Teplizumab as Part of Managed Access Programs (MAPs)
What is being tested: Teplizumab, an anti-CD3 monoclonal antibody, is being evaluated in real-world clinical practice through managed access programs to assess its effectiveness…
17 Apr 2026 NCT07457580
● Recruiting Cardiology / Cardiovascular
Post-Market Celect Platinum Vena Cava Filter and Gunther Tulip Retrieval Set Study
What is being tested: Real-world safety and performance data collection for two vena cava filter devices—the Celect Platinum Filter Sets and the Günther Tulip…
17 Apr 2026 NCT05881798
● Recruiting Phase III Cardiology / Cardiovascular
Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease
What is being tested: Orforglipron, a once-daily treatment, is being evaluated for its efficacy and safety in managing Fontaine II peripheral arterial disease (symptomatic…
17 Apr 2026 NCT07223593
● Recruiting Cardiology / Cardiovascular
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
What is being tested: A novel atrioventricular interval modulation (AVIM) algorithm integrated into dual-chamber pacemakers to evaluate its safety and effectiveness as a potential…
17 Apr 2026 NCT06059638
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)
What is being tested: Orforglipron (LY3502970), a GLP-1 receptor agonist, is being evaluated for its effects on cardiovascular outcomes compared to placebo over approximately…
17 Apr 2026 NCT07241390
● Recruiting Phase III Cardiology / Cardiovascular
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
What is being tested: AZD0780, an oral PCSK9 inhibitor, is being evaluated in a Phase III randomized controlled trial to assess its efficacy in…
17 Apr 2026 NCT07000357
● Recruiting Oncology
SPECTA: Screening Cancer Patients for Efficient Clinical Trial Access
What is being tested: SPECTA is a standardized biobank platform collecting high-quality annotated biological samples, imaging data, operative records, and patient-reported outcomes from cancer…
17 Apr 2026 NCT02834884
● Recruiting Phase I Oncology
A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
What is being tested: BNT329, an investigational drug designed to target CA19-9-expressing advanced solid tumors, with primary focus on establishing safety profile and optimal…
17 Apr 2026 NCT07186842