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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

2231 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

2231 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

● Recruiting Phase III Oncology
DAREON®-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer (epNEC) to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy
What is being tested: Obrixtamig (a DLL3-targeting therapy) combined with carboplatin and etoposide chemotherapy versus standard chemotherapy alone in patients with advanced extrapulmonary neuroendocrine…
22 Jul 2026 NCT07544654
● Recruiting Phase I Oncology
A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer
Drug being tested: PF-08052667 is a novel investigational medicine being evaluated as monotherapy or in combination with BCG (standard intravesical immunotherapy) and/or sasanlimab (an…
22 Jul 2026 NCT07206225
● Recruiting Phase I Oncology
A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)
What is being tested: Different dose combinations of BI 1703880 (an experimental medicine) with ezabenlimab (an existing immunotherapy) to determine tolerability and the maximum…
22 Jul 2026 NCT05471856
● Recruiting Phase II Oncology
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
What is being tested: Disitamab vedotin (a HER2-targeted antibody-drug conjugate) as monotherapy or in combination with pembrolizumab (PD-L1 inhibitor) for HER2-expressing urothelial cancer, evaluating…
22 Jul 2026 NCT04879329
● Recruiting Phase III
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of GM1 Gangliosidosis or GM2 Gangliosidosis
Oral nizubaglustat tested against placebo over 18 months in children with late-infantile or juvenile GM1/GM2 gangliosidosis.
21 Jul 2026 NCT07082543
● Recruiting Phase II
A 16-week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream 20 mg/g in Adult Participants With Mild to Severe Palmoplantar Pustulosis
Delgocitinib cream twice daily reduced symptoms of palmoplantar pustulosis more effectively than placebo cream over 16 weeks.
21 Jul 2026 NCT07013201
● Recruiting
PMCF (Post-Market Clinical Follow-up) Study on The Tether™ in UK (United Kingdom)
A study monitoring safety and effectiveness of The Tether™ device in UK patients undergoing surgery for childhood scoliosis.
21 Jul 2026 NCT05830825
active not recruiting Phase III Oncology
A Clinical Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) to Treat Newly-diagnosed Metastatic Non-small Cell Lung Cancer (MK-3475A-F84)
Trial comparing subcutaneous versus intravenous pembrolizumab delivery for newly-diagnosed metastatic non-small cell lung cancer.
21 Jul 2026 NCT06698042
● Recruiting Phase II
A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis
Trial testing efgartigimod injection versus placebo for systemic sclerosis over 48 weeks to assess safety and effectiveness.
21 Jul 2026 NCT06655155
active not recruiting Phase II Oncology
A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma
Trial testing new drug ABBV-400 combined with chemotherapy and immunotherapy for advanced stomach and gullet cancers.
21 Jul 2026 NCT06628310
● Recruiting Phase III
A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP
Trial comparing new drug empasiprubart against standard IVIg treatment for CIDP over 24 weeks, then all patients receive empasiprubart for 24 months.
21 Jul 2026 NCT06920004
active not recruiting Phase III Rheumatology
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
A drug called obinutuzumab added to standard lupus kidney treatment improved kidney function and was safe compared to placebo.
21 Jul 2026 NCT04221477
● Recruiting Rheumatology
Metagenomics for Ocular Inflammation
What is being tested: Metagenomic sequencing is being evaluated as a diagnostic tool to identify infectious agents in patients with ocular inflammation when standard…
21 Jul 2026 NCT06974162
● Recruiting Phase III Respiratory / COPD / Asthma
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
Treatment being tested: Tozorakimab (a monoclonal antibody) administered as an add-on to standard care in hospitalised patients with viral lung infection requiring supplemental oxygen,…
21 Jul 2026 NCT05624450
● Recruiting Phase I Oncology
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations
What is being tested: The safety and efficacy of T cell engaging bi/tri-specific antibodies administered intravenously or subcutaneously, either as monotherapy or in combination…
21 Jul 2026 NCT06892522
● Recruiting Cardiology / Cardiovascular
The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study
Testing early surgical aortic valve replacement in asymptomatic severe aortic stenosis patients versus the standard watchful waiting approach to determine whether proactive intervention improves…
21 Jul 2026 NCT04204915
● Recruiting Phase I Oncology
First Time in Human (FTIH) Study to Investigate the Safety and Preliminary Activity of GSK5533524 Alone or in Combination in Adult Participants With Advanced Solid Tumors
Drug Being Tested: GSK5533524, a novel investigational agent, is being evaluated in a first-in-human study as monotherapy and in combination regimens to establish safety,…
21 Jul 2026 NCT07438782
● Recruiting Oncology
DRAGON Registry – International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
What is being tested: Combined portal and hepatic vein embolization (PVE/HVE) as a preoperative strategy to increase future liver remnant volume before surgical resection…
21 Jul 2026 NCT07717437
● Recruiting Phase III Oncology
AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer
What is being tested: AZD5335 (a folate receptor alpha inhibitor) is compared against mirvetuximab soravtansine in FRα-high tumours and against chemotherapy in FRα-low tumours,…
21 Jul 2026 NCT07218809
● Recruiting
Post-market Evaluation of the Transition From the Baha Connect System to the Osia System in Adult Bone Conduction Implant Recipients
Study comparing safety and hearing improvement of newer Osia bone implant system versus older Baha Connect system in adults.
20 Jul 2026 NCT07130136
active not recruiting Phase III
24 Weeks Double-blind Randomized Placebo-controlled Trial to Evaluate Efficacy, PK, Safety of LOU064 in Adolescents (12 – <18) With CSU and Inadequate Response to H1-antihistamine Followed by Optional 3 Years Open-label Extension and an Optional 3 Years Safety Long-term Treatment-free Follow-up
Remibrutinib versus placebo for adolescent chronic urticaria inadequately controlled by antihistamines, with long-term safety follow-up.
20 Jul 2026 NCT05677451
active not recruiting Phase II
Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE)
Tibulizumab tested against placebo over 24 weeks in systemic sclerosis patients, with all then receiving active drug for 28 weeks.
20 Jul 2026 NCT06843239
● Recruiting Phase III Oncology
A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)
What is being tested: The trial evaluates belzutifan (MK-6482), a targeted therapy already used for RCC, combined with zanzalintinib (a new investigational agent) to…
20 Jul 2026 NCT07489495
● Recruiting Oncology
β2M Post-HD Rebound Prediction
What is being tested: A predictive model for β2-microglobulin (β2M) rebound kinetics following haemodialysis, aiming to forecast post-dialysis β2M levels based on patient and…
20 Jul 2026 NCT07713680
● Recruiting Phase III Respiratory / COPD / Asthma
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)
GB-0895 is being tested as an add-on therapy for adolescents and adults with severe asthma that remains uncontrolled despite treatment with inhaled corticosteroids and…
20 Jul 2026 NCT07359846
● Recruiting Phase IV Oncology
A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Drug being tested: Pirtobrutinib (LY3527727), a second-generation Bruton's tyrosine kinase (BTK) inhibitor, is being evaluated for long-term safety and tolerability in patients with previously…
20 Jul 2026 NCT07218341
● Recruiting Phase I Oncology
A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors
Drug and mechanism: LOXO-783 is being tested as a targeted therapy for breast cancer and solid tumors with specific genetic mutations, representing a precision…
20 Jul 2026 NCT05307705
active not recruiting Phase III Oncology
Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer
New drug combination XL092 plus atezolizumab compared to regorafenib for advanced bowel cancer that hasn't responded to standard treatment.
17 Jul 2026 NCT05425940
active not recruiting Phase III
A Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With Dermatomyositis
Brepocitinib, a new immune-suppressing drug, tested against placebo in adults with dermatomyositis over 52 weeks.
17 Jul 2026 NCT05437263
active not recruiting Phase III
A Study to Assess Safety, Tolerability and Efficacy of Garetosmab Versus Placebo Administered Intravenously (IV) in Adult Participants With Fibrodysplasia Ossificans Progressiva (FOP)
Garetosmab injection tested against placebo in adults with FOP to assess safety and effectiveness at slowing bone formation.
17 Jul 2026 NCT05394116
active not recruiting Phase I
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of UCB5285 in Healthy Study Participants
A safety and dose study of new drug UCB5285 in healthy people, including Japanese volunteers.
17 Jul 2026 NCT07286682
● Recruiting Phase I Gastroenterology
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
A new gene-editing treatment (VERVE-201) was tested in patients with severe high cholesterol to assess safety and whether it reduces cholesterol levels.
17 Jul 2026 NCT06451770
● Recruiting
Baseline Evaluation of Lymph Nodes in the Lower Quadrant Young People Using Point of Care Ultrasound (BELLY-POCUS)
Study establishing normal lymph node appearances on bedside ultrasound in children to help diagnose mesenteric adenitis.
17 Jul 2026 NCT07704814
active not recruiting Respiratory / COPD / Asthma
Is Hypoxemia Driving Outcome in Acute Hypoxemic Respiratory Failure? (HOMELAND Study)
Study examines whether low blood oxygen levels directly cause ICU deaths in respiratory failure patients, or if organ dysfunction is the real culprit.
17 Jul 2026 NCT07708506
● Recruiting Respiratory / COPD / Asthma
Longitudinal Population-based Observational Study of COVID-19 in the UK Population
What is being tested: COVIDENCE UK is an observational longitudinal study investigating risk factors for COVID-19 infection and adverse outcomes, whilst characterising the disease's…
17 Jul 2026 NCT04330599
● Recruiting Phase I Respiratory / COPD / Asthma
Development of a Controlled Human Infection Model for Assessment of SARS-CoV-2 Omicron Subvariants
What is being tested: A controlled human infection model (CHIM) administering SARS-CoV-2 Omicron EG.5.1 variant via intranasal drops to evaluate breakthrough infections and immune…
17 Jul 2026 NCT07397455
● Recruiting Cardiology / Cardiovascular
Barts Endocarditis Research Registry
What is being tested: The registry evaluates infective endocarditis (IE) characteristics, current imaging practices, and implementation of European Society of Cardiology (ESC) guidelines in…
17 Jul 2026 NCT06434012
● Recruiting Oncology
Exercise to Improve Outcomes in Pancreatic Cancer
What is being tested: A structured exercise programme delivered before and after Whipple's procedure (pancreatic cancer surgery) to determine whether prehabilitation and postoperative exercise…
17 Jul 2026 NCT07710495
active not recruiting Phase I / Phase II
A Safety and Efficacy Study of One-time SAR402663 in Adults With Neovascular Age-related Macular Degeneration
Single-dose gene therapy injection for wet age-related macular degeneration, with safety and vision outcomes tracked over five years.
16 Jul 2026 NCT06660667
● Recruiting Cardiology / Cardiovascular
Left Ventricular Thrombus Registry
Registry studying blood clots in weakened hearts after heart attack or heart failure to improve future treatment strategies.
16 Jul 2026 NCT06963567
● Recruiting Phase III
An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED
Cenegermin eye drops versus placebo for treating persistent corneal erosion, measuring complete healing at four weeks.
16 Jul 2026 NCT07519902
active not recruiting Phase III Oncology
A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW).
Zolbetuximab plus chemotherapy versus placebo plus chemotherapy for first-line treatment of advanced gastric or gastroesophageal junction cancer positive for Claudin 18.2.
16 Jul 2026 NCT03653507
● Recruiting
MEASuRE: Metreleptin Effectiveness And Safety Registry
A registry tracking safety and effectiveness of metreleptin treatment in patients across the US and Europe.
16 Jul 2026 NCT02325674
● Recruiting Phase III Oncology
A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy
What is being tested: Oral upadacitinib (a JAK inhibitor) is being evaluated for safety and efficacy in treating moderate to severe hidradenitis suppurativa in…
16 Jul 2026 NCT05889182
● Recruiting Phase II
A Trial to Compare Treatment With Surlorian (ARM210, S48168) to Placebo in Effects on Muscle Strength and Safety in Adults With Autosomal Dominant RYR1-related Myopathy
Surlorian tested against placebo for improving muscle strength and safety in adults with genetic RYR1-related muscle disease.
15 Jul 2026 NCT07560020
active not recruiting Cardiology / Cardiovascular
Precision Detection and Prediction of Atrial Arrhythmias Using Artificial Intelligence and Consumer Wearable Devices
AI-powered smartwatch analysis to improve atrial fibrillation detection and prediction in UK patients.
15 Jul 2026 NCT07291570
active not recruiting Phase III Neurology
A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-remitting Multiple Sclerosis (RRMS)
Ocrelizumab versus fingolimod for treating multiple sclerosis in children and teenagers over 24 weeks.
15 Jul 2026 NCT05123703
● Recruiting
Evaluation of Community Food Markets in Glasgow, Scotland.
Community food markets in Glasgow are being tested to see if they help low-income families buy and eat more fresh, healthy food.
15 Jul 2026 NCT07704736
active not recruiting Phase I
A Study to Evaluate the Safety, Tolerability, and Effects on Blood and Urine Markers of Single Ascending Dose of GSK4771261 in Healthy Participants and Participants With Autosomal Dominant Polycystic Kidney Disease
Phase 1 trial testing a new drug (GSK4771261) in healthy people and those with polycystic kidney disease to assess safety and effectiveness.
15 Jul 2026 NCT06734234
● Recruiting Phase III Oncology
VO and Nivolumab vs Physician’s Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]
IGNYTE-3 Trial Summary VO plus nivolumab versus standard treatment for melanoma that progressed after checkpoint inhibitor therapy.
15 Jul 2026 NCT06264180