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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

1963 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

1963 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

● Recruiting Phase III Oncology
A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy
What is being tested: IDRX-42 (GSK6042981), a novel investigational drug, is being evaluated against sunitinib (standard comparator) in adults with gastrointestinal stromal tumors (GIST)…
12 Jun 2026 NCT07218926
● Recruiting Phase III Oncology
A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study
What is being tested: Continued treatment with Roche investigational medicinal products (IMPs), either as monotherapy or in combination with other agents or comparators, in…
12 Jun 2026 NCT05862285
● Recruiting Phase II Oncology
Study of Olutasidenib and Temozolomide in HGG
What is being tested: Olutasidenib combined with temozolomide in newly diagnosed pediatric and young adult patients with IDH1-mutant high-grade gliomas (HGG), evaluating whether this…
12 Jun 2026 NCT06161974
active not recruiting Phase III Cardiology / Cardiovascular
A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.
Inclisiran injection reduces heart attacks, strokes, and cardiovascular deaths in high-risk patients without prior heart disease, compared to placebo.
12 Jun 2026 NCT05739383
● Recruiting
Global Prospective, Observational Cohort of Adult Patients With Primary Sclerosing Cholangitis (WIND-PSC Study)
Observational study establishing a real-world comparison group of PSC patients to help design and evaluate future PSC treatment trials.
12 Jun 2026 NCT06297993
● Recruiting Phase III Diabetes / Metabolic
Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
MET097 injected once weekly helped adults with obesity or overweight lose weight over 64 weeks of treatment.
12 Jun 2026 NCT07311850
active not recruiting Phase II
Study to Assess the Efficacy, Safety, and Tolerability of NOC-110 in Adults With Refractory or Unexplained Chronic Cough
New inhaled powder drug tested against placebo for treating persistent cough that hasn't responded to standard treatments.
12 Jun 2026 NCT06504446
active not recruiting Phase II Neurology
Venglustat in Combination With Cerezyme in Adult Patients With Gaucher Disease Type 3 With Venglustat Monotherapy Extension
Study tests whether adding venglustat to standard Gaucher disease treatment improves brain-related symptoms and safety in adults.
12 Jun 2026 NCT02843035
active not recruiting Phase II Respiratory / COPD / Asthma
Clairleafᵀᴹ: A Study to Test Long-term Treatment With BI 1291583 in People With Bronchiectasis Who Took Part in a Previous Study With This Medicine
Long-term safety and effectiveness study of BI 1291583 tablet in adults with bronchiectasis who completed previous trials.
12 Jun 2026 NCT05846230
● Recruiting Phase II Oncology
RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive
Treatment being tested: RO7771950 (a novel HER2-directed tyrosine kinase inhibitor) combined with trastuzumab and capecitabine, compared against the established standard tucatinib-based regimen in HER2-positive…
12 Jun 2026 NCT07413939
● Recruiting Phase II Respiratory / COPD / Asthma
A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants
What is being tested: OHB-607, an investigational drug designed to prevent Bronchopulmonary Dysplasia (BPD) in extremely premature infants, evaluated against standard neonatal care alone…
12 Jun 2026 NCT03253263
● Recruiting Respiratory / COPD / Asthma
Assessing the Efficacy of Photodynamic Therapy for Preventing Surgical Site Infections
What is being tested: Photodynamic therapy (PDT) using the Steriwave™ ND System to prevent surgical site infections in patients undergoing nasal surgery, compared with…
12 Jun 2026 NCT06731881
● Recruiting Cardiology / Cardiovascular
Biomedical Research Informatics Centre for Cardiovascular Sciences (The BRICCS Study)
What is being tested: The BRICCS Study examines diagnostic and prognostic factors in patients with established cardiovascular disease (coronary artery disease, heart failure, myocardial…
12 Jun 2026 NCT04388943
● Recruiting Phase I Oncology
Dose Determining Study of EXS73565 in Participants With Relapsed or Refractory B-Cell Malignancies
What is being tested: EXS73565 is an oral investigational agent being evaluated for safety, tolerability, pharmacokinetics, and antitumor activity in a dose-determining study in…
12 Jun 2026 NCT06980116
● Recruiting Phase I Oncology
Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma
Therapeutic Target: XmAb®819 is being tested as a potential treatment for advanced clear cell renal cell carcinoma (ccRCC), specifically in patients with relapsed or…
12 Jun 2026 NCT05433142
● Recruiting Phase III Oncology
An Extension Study for Patients Previously Enrolled in Studies With Pelabresib
What is being tested: Long-term safety and clinical benefit of pelabresib (a BET inhibitor) in patients with hematological and/or solid tumors, including evaluation of…
12 Jun 2026 NCT06401356
active not recruiting Oncology
Granulocyte Transfusions After Umbilical Cord Blood Transplant
Study testing whether white blood cell transfusions improve immune recovery and outcomes after cord blood stem cell transplant in children with leukaemia.
09 Jun 2026 NCT05425043
active not recruiting Phase I Oncology
Study to Evaluate Adverse Events, Change in Disease Activity, and How Oral ABBV-101 Moves Through the Body in Adult Participants With B-Cell Malignancies
Trial testing safety and effectiveness of oral ABBV-101 alone or combined with venetoclax in adults with relapsed/refractory non-Hodgkin's lymphoma.
09 Jun 2026 NCT05753501
● Recruiting Phase I Oncology
A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)
Trial testing loncastuximab tesirine combined with three other drugs in patients with hard-to-treat B-cell lymphoma to find safe, effective doses.
09 Jun 2026 NCT04970901
● Recruiting Phase III Rheumatology
A Study to Evaluate the Drug Levels, Efficacy and Safety of Deucravacitinib in Children and Adolescent Participants With Moderate to Severe Plaque Psoriasis
Trial testing deucravacitinib dosing, effectiveness and safety in children aged 4-17 with moderate-to-severe psoriasis over five years.
09 Jun 2026 NCT04772079
active not recruiting
Portico Next Generation Approval Study
Portico Next Generation Approval Study Study testing a new heart valve for high-risk patients, measuring safety at 30 days and leakage around the valve.
09 Jun 2026 NCT04011722
active not recruiting Oncology
Comprehensive Segmental Revision System
A study evaluating how well the Comprehensive Segmental Revision System works for complex spinal reconstruction surgery.
09 Jun 2026 NCT03270982
● Recruiting
An Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Treatment
Study tracking how routine preventative treatment works and affects quality of life in patients with Type 3 von Willebrand disease over 24 weeks.
09 Jun 2026 NCT06883240
● Recruiting Phase III Oncology
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Treatment being tested: Pirtobrutinib (LOXO-305), a novel BTK inhibitor, is being compared against ibrutinib (standard BTK inhibitor) in patients with chronic lymphocytic leukaemia/small lymphocytic…
09 Jun 2026 NCT05254743
● Recruiting Phase II Oncology
A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC
What is being tested: Adjuvant autogene cevumeran (personalised neoantigen vaccine) combined with atezolizumab (PD-L1 inhibitor) plus mFOLFIRINOX chemotherapy versus mFOLFIRINOX chemotherapy alone in patients…
09 Jun 2026 NCT05968326
● Recruiting Phase I Oncology
A Study to Learn How Safe AZD6621 is, How Well it Works, and How it Moves Throughout the Body Over Time, in Adult Male Participants With Metastatic Prostate Cancer
What is being tested: AZD6621, an experimental therapeutic agent, is undergoing evaluation for safety, tolerability, pharmacokinetics, and efficacy in adult male patients with metastatic…
09 Jun 2026 NCT07192614
active not recruiting Phase II Oncology
A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
Trial testing targeted cancer drugs based on tumour genetic markers in women with rare, recurrent ovarian cancer.
08 Jun 2026 NCT04931342
active not recruiting Phase III Neurology
Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis
Fingolimod was safer and more effective than interferon beta-1a for reducing MS relapses in children.
08 Jun 2026 NCT01892722
active not recruiting Phase I
Study of E7386 in Participants With Selected Advanced Neoplasms
A study testing an oral cancer drug (E7386) to find safe doses and assess side effects in patients with advanced cancers.
08 Jun 2026 NCT03264664
active not recruiting Phase III Oncology
A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Two drug combination therapy compared with single drug treatment for advanced lung cancer with specific genetic mutations.
08 Jun 2026 NCT04487080
● Recruiting Phase II
A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves’ Disease
New drug IMVT-1402 tested against placebo in patients with Graves' disease uncontrolled by standard thyroid medications.
08 Jun 2026 NCT07018323
active not recruiting Phase III
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients
Crizanlizumab at two different doses tested against placebo to reduce pain crises in adolescents and adults with sickle cell disease.
08 Jun 2026 NCT03814746
active not recruiting Phase II Oncology
A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate Cancer
Trial testing niraparib combined with other drugs to treat advanced prostate cancer resistant to hormone therapy.
08 Jun 2026 NCT03431350
active not recruiting Phase III Oncology
A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer
Trial comparing injected versus infused amivantamab with lazertinib for EGFR-mutated lung cancer, aiming to reduce treatment time.
08 Jun 2026 NCT05388669
active not recruiting Phase III Rheumatology
A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque Psoriasis
A trial testing whether JNJ-77242113 effectively treats moderate to severe plaque psoriasis in teenagers and adults.
08 Jun 2026 NCT06095115
active not recruiting Cardiology / Cardiovascular
Outcomes of Drug Coated Balloon Angioplasty, A UK Real Life Experience From 2009 to 2015
Drug-coated balloon angioplasty was safe and effective for treating coronary artery disease in this UK hospital study from 2009-2015.
08 Jun 2026 NCT03603210
● Recruiting Cardiology / Cardiovascular
Comparison of Allegra vs Sapien Transcatheter Aortic Valves in Valve-In-Valve Indication
What is being tested: Direct comparison of two transcatheter aortic valve (TAVI) systems—the self-expandable supra-annular Allegra valve versus the balloon-expandable intra-annular Edwards Sapien valve—in…
08 Jun 2026 NCT06049654
● Recruiting Phase III Oncology
Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC
What is being tested: A combination therapy of [225Ac]Ac-PSMA-617 (AAA817), an alpha-emitting radioligand targeting PSMA, plus an androgen receptor pathway inhibitor versus standard of…
08 Jun 2026 NCT06855277
● Recruiting Phase III Oncology
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
What is being tested: Sacituzumab tirumotecan (an antibody-drug conjugate) combined with pembrolizumab (an immune checkpoint inhibitor) as first-line maintenance therapy following chemotherapy in patients…
08 Jun 2026 NCT07216703
● Recruiting Phase III
A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)
Nipocalimab versus placebo for preventing severe haemolytic disease in at-risk pregnancies.
05 Jun 2026 NCT05912517
active not recruiting Phase III Oncology
A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy
Apalutamide with hormone therapy before and after prostate surgery improves cancer control in high-risk localised prostate cancer.
05 Jun 2026 NCT03767244
active not recruiting
Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms
Branched endografts (GORE EXCLUDER) successfully treat thoracoabdominal aortic aneurysms, offering minimally invasive alternative to open surgery.
05 Jun 2026 NCT03728985
active not recruiting
ATTUNE Revision System in the Revision Total Knee Arthroplasty Population
ATTUNE knee replacement prostheses showed acceptable five-year outcomes in revision surgery across two tibial design types.
05 Jun 2026 NCT03153475
active not recruiting Phase III Oncology
A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)
Trial comparing two new bladder cancer treatments (TAR-200 with or without cetrelimab) against standard BCG therapy in untreated high-risk patients.
05 Jun 2026 NCT05714202
active not recruiting Phase III
A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa
Remibrutinib reduces symptoms of severe hidradenitis suppurativa better than placebo, with acceptable safety in adults and teenagers.
05 Jun 2026 NCT06840392
active not recruiting Phase II Respiratory / COPD / Asthma
A Trial to Evaluate Efficacy and Safety of Buloxibutid in People With Idiopathic Pulmonary Fibrosis.
Buloxibutid tested against placebo over 52 weeks in IPF patients to assess whether it slows lung function decline and is safe to use.
05 Jun 2026 NCT06588686
active not recruiting Phase II Neurology
A Study to Learn About the Safety of BIIB080 Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer’s Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age
Trial testing BIIB080 injections to slow cognitive decline in people aged 50-80 with mild Alzheimer's disease or mild cognitive impairment.
05 Jun 2026 NCT05399888
● Recruiting Phase I Neurology
A Phase I Study in Healthy Volunteers and Parkinson’s Disease (PD) Patients.
What is being tested: MTX325 is being evaluated as a potential disease-modifying treatment for Parkinson's Disease, assessed initially in healthy volunteers for safety and…
05 Jun 2026 NCT07630545
● Recruiting Diabetes / Metabolic
Investigating Pathological Mechanisms in Non-alcoholic Fatty Liver Disease
What is being tested: The study investigates immune cell characteristics (tissue-resident and circulating), blood biomarkers, metabolic profiles, and microbiota composition (faecal and oral) to…
05 Jun 2026 NCT04141592
● Recruiting Phase III Rheumatology
A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn’s Disease
What is being tested: A head-to-head comparison of two IL-23 inhibitor monoclonal antibodies—guselkumab and risankizumab—to evaluate their efficacy and safety in treating moderately to…
05 Jun 2026 NCT07499232