Trial Radar

Drug being tested: Sacituzumab tirumotecan (MK-2870), a targeted antibody-drug conjugate, is being evaluated as monotherapy or in combination with other treatments for advanced or…

This study tracks how well efanesoctocog alfa prevents joint bleeds in haemophilia A patients receiving routine preventive treatment over the long term.

Clemizole added to standard treatment reduced seizures more than placebo in Dravet syndrome patients.

New drug SNDX-5613 combined with chemotherapy tested for safety and effectiveness in newly diagnosed acute myeloid leukaemia.

Long-term study evaluating Mim8, a new factor VIII replacement therapy, for preventing bleeds in haemophilia A patients with or without inhibitors.

Researchers are investigating how kidney injury develops after heart surgery using heart-lung machines by studying biomarkers in blood and urine samples.

Study testing whether working with horses improves emotional regulation and engagement in inpatients with emotionally unstable personality disorder.

Early-stage trial testing genetically-modified immune cells to treat severe autoimmune diseases (systemic sclerosis and rheumatoid arthritis).

Trial comparing new eye injection tiespectus against standard aflibercept treatment for wet age-related macular degeneration.

PS-002 is a novel therapeutic agent being tested in a first-in-human trial to evaluate its safety, tolerability, and preliminary effectiveness in treating primary IgA…

What is being tested: Novel diagnostic technologies designed to improve the speed and accuracy of identifying respiratory viruses, addressing limitations of current detection methods…

What is being tested: Nitrate-rich beetroot juice supplementation as a potential intervention to improve exercise capacity in IPF patients, building on evidence that interval-based…

What is being tested: VX-880 is an investigational infusion therapy being evaluated for safety, tolerability, and efficacy in treating Type 1 diabetes, specifically targeting…

What is being tested: The study evaluates whether personalised monitoring of cerebral autoregulation during cardiac surgery—using NIRS and transcranial Doppler to identify individual MAP…

What is being tested: The trial investigates how individual patients respond differently to low-carbohydrate (ketogenic) diets in terms of LDL-cholesterol changes, recognising that the…

What is being tested: NNC0487-0111, a novel investigational therapy, is being evaluated against placebo for safety and efficacy in patients with HFpEF or HFmrEF…

Treatment being tested: Tebentafusp (a TCR-engineered T-cell therapy) as adjuvant therapy following primary treatment in patients with high-risk uveal melanoma, aiming to prevent recurrence…

What is being tested: Post-market performance and safety data for Medtronic devices used in cranial and spinal surgical procedures, with patient follow-up extending to…

What is being tested: Multiple anti-cancer agents are being evaluated for safety, tolerability, pharmacokinetics, and preliminary efficacy in a platform study design, allowing simultaneous…

Adding lurbinectedin to atezolizumab maintenance therapy versus atezolizumab alone for extensive-stage small-cell lung cancer after initial chemotherapy.

Resistance band exercises improved muscle strength and balance in older adults with weak muscles.

Long-term study testing whether atumelnant is safe and effective for treating congenital adrenal hyperplasia.

Registry tracking pain relief outcomes in patients having frozen nerve treatment for post-surgical chest pain.

What is being tested: AAV2-GDNF is a gene therapy delivered surgically to the putamen (a key brain region affected in Parkinson's Disease) to potentially…

What is being tested: The clinical utility of circulating tumour DNA (ctDNA) analysis from blood samples to detect cancer resistance mechanisms and guide precision…

Treatment being tested: Sonlicromanol, a novel investigational medicine designed to reduce fatigue symptoms and improve physical function (including balance control) in patients with primary…

What is being tested: CryptiVax-1001, an immunotherapeutic vaccine, is being evaluated as a maintenance treatment in patients with advanced high-grade serous ovarian, fallopian tube,…

What is being tested: Endoscopic submucosal dissection (ESD) effectiveness and safety as a treatment approach for early gastrointestinal neoplasia across multiple UK centres in…

Trial testing pembrolizumab combined with various drugs to treat advanced prostate cancer resistant to hormone therapy.

Trial comparing two manufacturing methods of teclistamab to ensure the new process produces equivalent drug with same effectiveness in multiple myeloma.

Two new drugs tested together in hepatitis D patients to check if they're safe and effective.

Two new mRNA vaccines against RSV and related respiratory viruses are being tested for safety and effectiveness in infants aged 5-24 months.

Drug and indication: HLD-0915 is being tested for safety and efficacy in metastatic prostate cancer patients who have failed previous systemic treatments, with planned…

Drug being tested: Etrasimod, a selective sphingosine-1-phosphate receptor modulator, is being evaluated for safety, efficacy, and pharmacokinetics in children aged 2 to <12 years…

Treatment being tested: Intranasal ETH47, a novel therapeutic agent administered via nasal spray, designed to prevent asthma symptom development triggered by rhinovirus infection in…

PC14586 (rezatapopt) is being evaluated as a monotherapy in patients with advanced solid tumors carrying the TP53 Y220C mutation, targeting restoration of mutant p53…

What is being tested: ORBITA-SOLAR investigates whether individual coronary stenoses have unique angina thresholds by measuring the specific degree of coronary flow reduction needed…

What is being tested: Deucrictibant XR (extended-release) tablet for preventative treatment and deucrictibant IR (immediate-release) capsule for acute attack management in acquired angioedema due…

What is being tested: The PRECEDE Consortium is investigating early detection and prevention strategies for pancreatic ductal adenocarcinoma (PDAC) in high-risk populations, including individuals…

Treatment being tested: YTB323, a novel CAR-T cell therapy designed to target and eliminate autoreactive B cells in treatment-resistant generalized myasthenia gravis (gMG), representing…

New drug JNJ-77242113 tested for treating psoriasis in difficult-to-treat areas like scalp, genitals, palms and soles.

Early-stage trial testing vimseltinib drug in patients with advanced cancers and tenosynovial giant cell tumours to find safe doses and effectiveness.

Tralokinumab injections plus steroid cream safely and effectively treat moderate-to-severe eczema in young children and infants.

PLINTH Study Summary This feasibility study tests whether a platform trial design is acceptable and workable for treating brain haemorrhage stroke survivors.

Efruxifermin tested against placebo in 1,650 patients with liver scarring from fatty liver disease (stages 2-3, non-cirrhotic).

New cancer drug GSK4381562 tested for first time in humans with advanced tumours to check safety and how the body processes it.

Being tested: Safety, tolerability, pharmacokinetics, immunogenicity, and pharmacodynamics of a new subcutaneous formulation of ocrelizumab (an anti-CD20 monoclonal antibody) in multiple sclerosis patients, with…

What is being tested: AZD2373, a novel therapeutic agent, is undergoing dose-ranging evaluation for safety, tolerability, and efficacy specifically in APOL1-mediated kidney disease, targeting…

Treatment being tested: AZD8965 at three different doses versus placebo in patients with idiopathic pulmonary fibrosis (IPF), assessed for efficacy, safety, and tolerability, with…

What is being tested: Therapeutic equivalence of CHF5993 pMDI (a combination inhaler containing beclomethasone/formoterol/glycopyrronium) formulated with HFA-152a propellant versus the standard formulation, to confirm…