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Trial Radar • ClinicalTrials.gov • Registry-linked

Trial Radar

2236 clinical trials with phase, status, specialty and registry links, summarised for rapid clinical review.

2236 recruiting AI clinical summaries
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All Phases Phase I Phase II Phase III Phase IV
Therapeutic Area: All Cardiology / Cardiovascular Dermatology Diabetes / Metabolic Gastroenterology Haematology Infectious Disease Men's Health Mental Health / Psychiatry Nephrology Neurology Oncology Rare Diseases
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Trial Radar

Clinical Trial Intelligence

● Recruiting Phase II Oncology
A Study of Efgartigimod PH20 SC in Children Between 2 and Less Than 18 Years of Age With Generalized Myasthenia Gravis
Treatment being tested: Efgartigimod PH20 (subcutaneous formulation) – a neonatal Fc receptor (FcRn) inhibitor designed to reduce IgG antibodies in generalized myasthenia gravis (gMG)…
27 Apr 2026 NCT06392386
● Recruiting Phase III Oncology
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
What is being tested: JNJ-90301900 (NBTXR3), a nanoparticle therapy activated by radiotherapy, combined with standard radiation therapy ± cetuximab versus radiation therapy ± cetuximab…
27 Apr 2026 NCT04892173
● Recruiting Phase III Oncology
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
What is being tested: The addition of INCB161734 (a KRAS G12D inhibitor) to standard chemotherapy versus chemotherapy alone in patients with metastatic pancreatic cancer…
27 Apr 2026 NCT07522073
● Recruiting Phase I / Phase II
Study of KITE-363 or KITE-753 in Participants With Relapsed and/or Refractory B-cell Lymphoma
Trial testing two new cell therapies (KITE-363 and KITE-753) for B-cell lymphoma that hasn't responded to standard treatment.
24 Apr 2026 NCT04989803
● Recruiting Phase III
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
New anti-inflammatory injection (itepekimab) tested alongside steroid nasal spray for difficult-to-treat nasal polyps over one year.
24 Apr 2026 NCT06834360
active not recruiting Phase II
A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes (LR-MDS)
A trial testing whether tebapivat reduces blood transfusion needs in patients with low-risk bone marrow disorders.
24 Apr 2026 NCT05490446
● Recruiting Phase III
REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome
ION582 improved seizures, sleep and developmental outcomes in Angelman syndrome patients with UBE3A deletions or mutations.
24 Apr 2026 NCT06914609
active not recruiting Phase II / Phase III
An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)
Diacerein ointment tested for safety and effectiveness in treating generalized epidermolysis bullosa simplex blistering disorder.
24 Apr 2026 NCT06073132
active not recruiting Phase I / Phase II Oncology
A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer
Trial testing durvalumab combinations versus standard chemotherapy in patients with advanced triple negative breast cancer.
24 Apr 2026 NCT03742102
● Recruiting Phase II Dermatology
A Dose-ranging Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Galvokimig in Adult Study Participants With Atopic Dermatitis
Trial testing different doses of galvokimig versus placebo in adults with moderate-to-severe eczema to find the most effective safe dose.
24 Apr 2026 NCT07277660
● Recruiting Phase I
A Study to Investigate Andexanet Dosing and the Interaction Between Andexanet and Subsequent Enoxaparin in Healthy Participants
Andexanet alfa dosing study examining how it interacts with subsequent enoxaparin treatment in healthy volunteers.
24 Apr 2026 NCT07312851
active not recruiting Phase I
Multi-modular Chimeric Antigen Receptor Targeting GD2 in Neuroblastoma
A trial testing a new engineered cell therapy for children with difficult-to-treat neuroblastoma, focusing on safety and feasibility.
24 Apr 2026 NCT05990751
active not recruiting Phase I Infectious Disease
COVID-19 Omicron BA.5 Subvariant Dose Finding Infection Study
Researchers tested different doses of Omicron BA.5 virus in vaccinated volunteers to find the optimal dose for future COVID vaccine studies.
24 Apr 2026 NCT06478420
● Recruiting Phase III Gastroenterology
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
What is being tested: Efruxifermin (EFX), an FGF21 analogue, is being evaluated in a randomized controlled trial to assess its efficacy and safety in…
24 Apr 2026 NCT06528314
● Recruiting Phase II Respiratory / COPD / Asthma
Imlifidase Prior to Kidney Transplant in Highly Sensitised Children
What is being tested: Imlifidase, an IgG-degrading enzyme, is being evaluated for its efficacy and safety in enabling successful kidney transplantation in highly sensitized…
24 Apr 2026 NCT05753930
● Recruiting Phase III Cardiology / Cardiovascular
A Study of Migalastat in Pediatric Subjects (2 to
What is being tested: Migalastat, a pharmacological chaperone, is being evaluated for safety, pharmacokinetics, pharmacodynamics, and efficacy in treating paediatric Fabry disease patients aged…
24 Apr 2026 NCT06904261
● Recruiting Cardiology / Cardiovascular
Neurovascular Product Surveillance Registry
What is being tested: This is a post-market surveillance registry monitoring the safety and performance of neurovascular products already in clinical use, rather than…
24 Apr 2026 NCT02988128
● Recruiting Phase IV Cardiology / Cardiovascular
THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE)
Treatment being tested: Thromboprophylaxis (blood clot prevention strategies) in patients undergoing endovenous interventions for superficial varicose veins, which are minimally invasive keyhole procedures performed…
24 Apr 2026 NCT05735639
● Recruiting Phase I Oncology
KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortumab Vedotin and Pembrolizumab in People With Urothelial Cancer (MK-3475-04D/KEYMAKER-U04)
What is being tested: Novel treatment combinations pairing enfortumab vedotin with pembrolizumab, investigating whether additional agents can improve outcomes in locally advanced or metastatic…
24 Apr 2026 NCT07232602
● Recruiting Phase II Oncology
Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for Patients With Non-small Cell Lung Cancer in Combination With Chemotherapy as First-line or Second-line Treatment
What is being tested: Pumitamig (BNT327), a novel investigational therapy, combined with chemotherapy as first-line or second-line treatment in advanced/metastatic NSCLC, with evaluation of…
24 Apr 2026 NCT06841055
● Recruiting Phase III Oncology
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
What is being tested: ARTEMIDE-Lung04 evaluates rilvegostomig (a novel immunotherapy agent) versus pembrolizumab monotherapy as first-line treatment in patients with metastatic non-small cell lung…
24 Apr 2026 NCT06868277
● Recruiting Phase III Oncology
Mocravimod as Adjunctive and Maintenance Treatment in AML Patients Undergoing Allo-HCT
What is being tested: Mocravimod, a TLR7 agonist, is being evaluated as an adjunctive and maintenance therapy in acute myeloid leukaemia (AML) patients undergoing…
24 Apr 2026 NCT05429632
● Recruiting Phase III Oncology
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
What is being tested: Long-term safety and efficacy of pembrolizumab (an anti-PD-1 immunotherapy) in patients with advanced tumors who are continuing treatment or follow-up…
24 Apr 2026 NCT03486873
● Recruiting Phase II / Phase III
A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)
A trial testing whether an oral cholesterol-lowering drug is safe and effective in children and teenagers with familial high cholesterol.
23 Apr 2026 NCT07058077
active not recruiting Phase III Oncology
A Global Study to Assess the Effects of Osimertinib in Participants With EGFRm Stage IA2-IA3 NSCLC Following Complete Tumour Resection
Osimertinib after surgery improves survival in early-stage lung cancer patients with specific EGFR mutations.
23 Apr 2026 NCT05120349
active not recruiting Phase II / Phase III
A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)
Mitapivat tested in sickle cell patients to increase haemoglobin levels and reduce painful crisis episodes compared to placebo.
23 Apr 2026 NCT05031780
active not recruiting Phase II
A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD)
Trial testing tebapivat against placebo in sickle cell disease patients to find the best dose for improving hemoglobin levels.
23 Apr 2026 NCT06924970
active not recruiting Rheumatology
The UK ADAPTIS Study
Study evaluating a new ankle replacement implant design in NHS patients to assess its performance and durability.
23 Apr 2026 NCT06941558
● Recruiting Phase III Gastroenterology
A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis
Trial testing a new drug (Afimkibart) for treating moderate-to-severe ulcerative colitis in children, measuring safety and effectiveness.
23 Apr 2026 NCT07158242
active not recruiting Phase II Rheumatology
An Adaptive Phase 2a/2b Study of LY3871801 in Adult Participants With Rheumatoid Arthritis
A new drug (LY3871801) is being tested for safety and effectiveness in adults with moderate-to-severe rheumatoid arthritis.
23 Apr 2026 NCT05848258
● Recruiting Phase III Respiratory / COPD / Asthma
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
What is being tested: Depemokimab, a monoclonal antibody, is being evaluated for its effects on airway structure and function in asthma patients using imaging…
23 Apr 2026 NCT06979323
● Recruiting Phase II Respiratory / COPD / Asthma
A Study of KT-621 Administered Orally to Adult Participants With Moderate to Severe Eosinophilic Asthma
What is being tested: KT-621, an oral investigational agent, is being evaluated in a Phase 2b trial to assess its safety and efficacy in…
23 Apr 2026 NCT07323654
● Recruiting Phase IV Respiratory / COPD / Asthma
Dosing of Steroids for Acute Asthma Given in the Emergency Department – a Pilot Randomised Feasibility Trial of Dexamethasone in Children
What is being tested: A pilot feasibility trial comparing dexamethasone (single-dose steroid) versus standard oral steroids for treating acute asthma exacerbations in children presenting…
23 Apr 2026 NCT07402707
● Recruiting Phase II Oncology
DETERMINE Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With HER2 Amplification or Activating Mutations
What is being tested: The efficacy and safety of combined trastuzumab and pertuzumab (two HER2-targeted monoclonal antibodies) across multiple cancer types with HER2 amplification…
23 Apr 2026 NCT05786716
● Recruiting Phase II Infectious Disease
A Clinical Trial of Extended (High) Treatment Dose Antibiotics in Combination With Methenamine Hippurate Compared to the Standard of Care (Either Prophylactic (Low) Dose Antibiotic Treatment or Methenamine Hippurate) in Females With Chronic Urinary Tract Infection
What is being tested: Extended high-dose antibiotic treatment combined with methenamine hippurate versus standard care (low-dose prophylactic antibiotics or methenamine hippurate alone) for managing…
23 Apr 2026 NCT07202949
● Recruiting Cardiology / Cardiovascular
Structured Review: To Optimise Management and Prevent Harm in COPD
What is being tested: A structured review intervention designed to optimise COPD management and prevent harm, focusing on reducing exacerbations and improving outcomes in…
23 Apr 2026 NCT07460154
● Recruiting Phase I Oncology
Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors
What is being tested: GTAEXS617 (REC-617), a novel therapeutic agent, is being evaluated for safety, tolerability, pharmacokinetics, and anti-tumor activity in patients with advanced…
23 Apr 2026 NCT05985655
● Recruiting Phase I Oncology
Study of STP938 in Advanced Solid Tumours
What is being tested: STP938 is an investigational drug being evaluated in a Phase 1 dose escalation and safety expansion study as a monotherapy…
23 Apr 2026 NCT06297525
● Recruiting Phase III Oncology
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
Treatment being tested: Sonrotoclax (a BCL2 inhibitor) combined with zanubrutinib (a BTK inhibitor) versus placebo plus zanubrutinib alone in adults with relapsed/refractory mantle cell…
23 Apr 2026 NCT06742996
● Recruiting Phase III Oncology
Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)
What is being tested: Sacituzumab tirumotecan (an antibody-drug conjugate targeting Trop-2) compared against standard chemotherapy (docetaxel or pemetrexed) in previously-treated advanced/metastatic nonsquamous NSCLC patients…
23 Apr 2026 NCT06074588
● Recruiting Phase I Oncology
Study for AZD4360 in Participants With Advanced Solid Tumours
What is being tested: AZD4360, a novel therapeutic agent, is being evaluated for safety, tolerability, pharmacokinetics, immunogenicity, and preliminary efficacy in patients with advanced…
23 Apr 2026 NCT06921928
● Recruiting Phase II Oncology
A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma
What is being tested: Novel agents or novel combination therapies administered perioperatively (before and after surgery) in patients with locally advanced resectable gastric, gastroesophageal…
23 Apr 2026 NCT07069712
● Recruiting Phase III Oncology
A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC
Treatment being tested: Durvalumab combined with domvanalimab (a novel anti-CTLA-4 immune checkpoint inhibitor) versus durvalumab alone, given after concurrent chemoradiation in patients with unresectable…
23 Apr 2026 NCT05211895
active not recruiting Phase III
Efficacy and Safety in Imlifidase Desensitized Kidney Tx Patients, Including Two Non-Comparative Reference Cohorts
Imlifidase allows highly sensitized kidney transplant patients with positive crossmatch to receive transplants safely, with good one-year graft survival.
22 Apr 2026 NCT05369975
● Recruiting Phase I / Phase II
Safety, Tolerability, PK and PD of ADX-038 in Healthy Participants and Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients
ADX-038, a new drug for rare blood disorder PNH, was tested for safety and effectiveness in healthy people and patients.
22 Apr 2026 NCT05876312
● Recruiting Phase III Mental Health / Psychiatry
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
New psilocin-based drug CYB003 tested against placebo for treating depression as an add-on therapy.
22 Apr 2026 NCT06793397
● Recruiting Phase II
A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves’ Disease
New drug IMVT-1402 tested against placebo in adults with Graves' disease uncontrolled by standard thyroid medications.
22 Apr 2026 NCT06727604
● Recruiting Phase II
A Study of Momelotinib in Participants With Low-risk Myelodysplastic Syndrome
Momelotinib tested for safety and effectiveness in reducing blood transfusion needs in early-stage myelodysplastic syndrome patients.
22 Apr 2026 NCT06847867
active not recruiting Rheumatology
Persona Partial Knee Clinical Outcomes Study
Persona Partial Knee implants show good survival rates and clinical outcomes in patients needing partial knee replacement surgery.
22 Apr 2026 NCT03034811
active not recruiting Phase III
Study of Ianalumab Versus Placebo in Addition to First-line Corticosteroids in Primary Immune Thrombocytopenia (ITP)
Ianalumab added to steroids didn't improve platelet counts better than steroids alone in newly diagnosed ITP patients.
22 Apr 2026 NCT05653349