Trial Radar

What is being tested: Real-world safety, effectiveness, and patient treatment experience with BRIUMVI® (ublituximab-xiiy), a CD20-targeting B-cell depleting monoclonal antibody, in patients with relapsing…

Treatment being tested: Triple combination of visugromab (anti-VEGF-C monoclonal antibody), nivolumab (anti-PD-1), and lenvatinib (tyrosine kinase inhibitor) versus lenvatinib monotherapy plus placebo in treatment-resistant…

Treatment being tested: Nerandomilast, a novel therapeutic agent, is being investigated for its efficacy in slowing disease progression in fibrosing interstitial lung disease (excluding…

What is being tested: The DIRECT study evaluates optimal prevention strategies for thrombosis (blood clots) in patients with hip fractures through a randomised crossover…

What is being tested: Orbital atherectomy (OA), a minimally invasive procedure using a small spinning device for plaque removal, is being evaluated in real-world…

What is being tested: Esprit BTK™ Everolimus Eluting Resorbable Scaffolds are being evaluated in a European multicentre study of 400 patients to assess their…

Single eye injection of SAR446597 tested for safety and effectiveness in age-related macular degeneration vision loss over two years.

Phenytoin and itraconazole significantly alter pelabresib blood levels; phenytoin reduces levels while itraconazole increases them in healthy volunteers.

Iptacopan tested to prevent progression of early-to-intermediate age-related macular degeneration to advanced vision loss.

What is being tested: N-WATCH evaluates novel tidal breathing techniques for improved diagnosis and monitoring of long-term paediatric lung diseases, particularly asthma, as an…

Intervention tested: An EPA-enriched (eicosapentaenoic acid) nutritional intervention is being evaluated in a randomised controlled trial to address malnutrition in cancer patients, with the…

What is being tested: The DIALIVE 2.0 liver dialysis device, an extracorporeal liver support system designed to be used alongside standard care in patients…

Treatment being tested: AZD6234, a novel investigational agent, is being evaluated for its efficacy and safety in reducing body weight compared to placebo over…

What is being tested: Catheter ablation with pulmonary vein isolation compared to DC cardioversion alone in patients with persistent atrial fibrillation, measuring AF recurrence…

What is being tested: The study evaluates whether pre-procedure CT scans and transthoracic echocardiography (TTE) can accurately predict outcomes and guide patient selection for…

What is being tested: Setidegrasib, a KRAS inhibitor, combined with either mFOLFIRINOX or NALIRIFOX chemotherapy regimens in patients with metastatic pancreatic cancer to evaluate…

Erenumab reduced monthly migraine days more than placebo in children and teenagers aged 6-17 with episodic migraines.

Trial testing JNJ-77242113 against placebo and deucravacitinib for moderate to severe plaque psoriasis effectiveness.

Gene therapy for inherited eye disease causing vision loss in males, testing safety and effectiveness in children and adults.

Early-stage trial testing whether AZD5305 PARP inhibitor works alone or combined with other cancer drugs in advanced solid tumors.

What is being tested: A combination therapy of TAK-242 (a TLR4 antagonist) plus G-CSF (granulocyte-colony stimulating factor) added to standard ACLF treatment, compared to…

What is being tested: This feasibility study captures bronchoscopy procedural data (CT scans and endoscopy videos) from patients and bronchoscopists over three years to…

Treatment being tested: Lunsekimig, a novel therapeutic agent being evaluated for long-term safety and efficacy in adults with eosinophilic COPD that remains inadequately controlled…

What is being tested: SALTIRE is investigating the underlying mechanisms driving aortic stenosis progression and post-valve replacement outcomes through longitudinal imaging (echocardiography every 6…

What is being tested: JX10, a novel therapeutic agent, is being evaluated against placebo in acute ischemic stroke patients to assess its safety and…

What is being tested: The ChemoINTEL assay, which measures in vitro cytotoxic drug-induced apoptosis and cell death in fresh colorectal cancer tumour cells to…

New friction-based crown system (Acuris) for single tooth implants shows good survival rates at one year without cement or screws.

Study measuring antibody and biomarker levels in blood of adults with late-onset Pompe disease to assess gene therapy readiness.

Trial testing whether new medicine Inno8 is safe and effective at different doses for haemophilia A patients.

Elritercept versus epoetin alfa for reducing blood transfusion needs in low-risk myelodysplastic syndrome anaemia.

Early trial testing whether afimkibart affects how the body breaks down common medicines in ulcerative colitis patients.

Restricting non-resuscitation fluids in septic shock patients may improve outcomes compared to standard fluid management.

What is being tested: Fibrosis-associated protein inhibitor (FAPI) radiotracer imaging as a novel diagnostic tool to identify and characterise fibrotic strictures in Crohn's Disease…

What is being tested: The clinical impact of retained endogenous insulin production (measured by C-peptide levels) on quality of life and health outcomes in…

What is being tested: Manganese-enhanced MRI imaging to investigate the physiological mechanisms of takotsubo cardiomyopathy (broken heart syndrome) and evaluate how different cardiac medications…

What is being tested: Novel imaging techniques to characterise inflammation, microcalcification, and thrombus activity within atherosclerotic plaques across peripheral and systemic vascular territories in…

What is being tested: Long-term safety and efficacy outcomes in pediatric and adult patients previously treated with gene-modified T-cell therapy through Celgene-sponsored clinical trials,…

What is being tested: MEN1703 (SEL24/Dapolsertib hydrochloride), a novel agent being evaluated as monotherapy or in combination with glofitamab, assessing safety and anti-lymphoma activity…

PLG0206 tested as wound irrigation during knee implant infection surgery to prevent reinfection and improve outcomes.

Researchers investigate why some bee-sensitized beekeepers develop severe allergic reactions to stings while others remain protected.

Elamipretide daily injections slow photoreceptor loss in dry age-related macular degeneration compared with placebo.

Study evaluates strength recovery and function 12-15 months after non-surgical Achilles tendon rupture treatment using the SMART protocol.

Long-term safety and performance study of Exactech shoulder replacements, following patients for at least 10 years.

Long-term safety and effectiveness of pozelimab and cemdisiran combination treatment in adults with paroxysmal nocturnal haemoglobinuria.

A 16-week study testing whether a nutritional supplement helps adults lose weight or prevent regain after stopping GLP-1 medications.

What is being tested: Concordance between international asthma diagnostic guidelines and evaluation of additional non-guideline physiologic measures (impulse oscillometry/IOS) to detect airways disease beyond…

What is being tested: The study evaluates whether breast biomechanics can be reliably measured and assessed in women who have undergone breast cancer treatment…

What is being tested: Development and validation of a flow cytometry-based test to quantify B-regulatory cells (Bregs) in blood samples from allergic patients undergoing…

What is being tested: The safety and efficacy of a lower INR target range (1.5-2.5) compared to standard anticoagulation in patients with mechanical bileaflet…

What is being tested: Safety and effectiveness of the Zenith® Fenestrated+ Endovascular Graft (ZFEN+) combined with the BeGraft Balloon-Expandable FEVAR Bridging Stent Graft System…